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首页> 外文学位 >Tug of War at Air-Water Interface: Understanding Lipid-Nanoparticle and Lipid-Protein Interaction Associated With Lung Surfactants at a Molecular Level.
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Tug of War at Air-Water Interface: Understanding Lipid-Nanoparticle and Lipid-Protein Interaction Associated With Lung Surfactants at a Molecular Level.

机译：空气-水界面处的拔河比赛：从分子水平理解与肺表面活性剂相关的脂质-纳米颗粒和脂质-蛋白质相互作用。

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摘要

Lung surfactants [LS] are a complex mixture of lipids and proteins that line the air-water interface in the alveoli of the lungs. They lower the work of breathing by reducing the surface tension and also form a line of defense against particles small enough to enter the respiratory tract. A deficiency of LS may lead to the fatal Neonatal Respiratory Distress Syndrome [NRDS] in premature infants, whereas, an impairment may cause Acute Respiratory Distress Syndrome [ARDS], irrespective of the age. Medical intervention in the form of Surfactant Replacement Therapy [SRT] becomes a lifesaver in such cases. Developing synthetic LS with efficacy in treating ARDS has therefore been a focus of this work. Further, with the rapid development in commercial and biomedical applications of engineered nanoparticles (ENPs), concerns regarding the effect of inhaled nanoparticles on LS function also need to be addressed. In this work, we have used a carbon-based ENP to understand their interactions with model LS. Our studies revealed that the alkyl chain saturation and head group charge of the phospholipids that form the major components of the LS play modulate phospholipid-nanoparticle interactions. We monitored the effect of Engineered Carbon Nanodiamonds [ECN] on five lipid compositions. In a zwitterionic environment, the nanoparticle was line active and favored the phospholipid domain boundaries. However, in an anionic environment, the nanoparticles reduced the packing density between domains. The electrostatic charge interaction was found to be more dominant.;We also observed the tug of war between a synthetic surfactant protein (analog of natural surfactant protein, SPB) called MiniB and cholesterol. MiniB increased the line tension of the domains whereas cholesterol reduced the same. MiniB also helped in forming reversible collapse at low surface tension, which in turn saved material loss to the bulk. A lower concentration of both proved to be effective in increasing the surface activity of LS.
机译：肺表面活性剂[LS]是脂质和蛋白质的复杂混合物，排列在肺泡的空气-水界面中。它们通过降低表面张力来降低呼吸功，并形成防线以防小到足以进入呼吸道的颗粒。 LS缺乏可能导致早产儿致命的新生儿呼吸窘迫综合症[NRDS]，而这种损害可能会导致不论年龄大小的急性呼吸窘迫综合症[ARDS]。在这种情况下，以表面活性剂替代疗法[SRT]形式进行的医学干预将成为救生员。因此，开发具有治疗ARDS功效的合成LS是这项工作的重点。此外，随着工程化纳米颗粒（ENP）在商业和生物医学应用中的快速发展，还需要解决有关吸入纳米颗粒对LS功能的影响的担忧。在这项工作中，我们使用了基于碳的ENP来了解它们与LS模型的相互作用。我们的研究表明，构成LS主要成分的磷脂的烷基链饱和度和头部基团电荷起着调节磷脂与纳米粒子相互作用的作用。我们监测了工程碳纳米金刚石[ECN]对五种脂质成分的影响。在两性离子环境中，纳米粒子具有线活性，并且倾向于磷脂域边界。然而，在阴离子环境中，纳米颗粒降低了畴之间的堆积密度。人们发现，静电荷相互作用更为主要。我们还观察到了合成的表面活性剂蛋白（天然表面活性剂蛋白SPB）与MiniB之间的拔河比赛。 MiniB增加了区域的线张力，而胆固醇降低了线张力。 MiniB还有助于在低表面张力下形成可逆的塌陷，进而节省了散装材料的损失。两者的较低浓度均被证明可有效提高LS的表面活性。

著录项

  • 作者

    Chakraborty, Aishik.;

  • 作者单位

    University of Kansas.;

  • 授予单位 University of Kansas.;
  • 学科 Chemical engineering.
  • 学位 M.S.
  • 年度 2015
  • 页码 93 p.
  • 总页数 93
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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