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Phytochemical analysis of antileishmanial plants: A drug discovery approach.

机译：抗菊科植物的植物化学分析：一种药物发现方法。

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Phytochemical analysis of three antileishmanial plants from Monteverde, Costa Rica and Abaco Island, Bahamas, has been carried out by use of column chromatography for phytoseparation, and NMR and IR spectroscopy for structural elucidation. Ruyschia phylladenia contained betulinic acid as major component, with significant amount of lupeol. Eugenia monteverdensis contained beta-Sitosterol, betulinic acid and barbinervic acid. Tabebuia bahamensis contained large amount of ursolic acid. Betulinic acid inhibited promastigotes of L. amazonensis significantly but was also toxic to mouse macrophages. Lupeol and betulinic acid did not show antimicrobial activity while beta-Sitosterol inhibited Aspergillus niger strongly. Barbinervic acid expressed good inhibition of Bacillus cereus. Ursolic acid was very active against MCF-7 cancer cells and inhibited Staphylococcus aureus significantly. R. phylladenia and T. bahamensis stand out as major sources of medicinally important compounds betulinic acid and ursolic acid respectively.

机译：通过柱色谱法进行植物分离，并用NMR和IR光谱法进行结构鉴定，对来自哥斯达黎加的蒙特维德和巴哈马的Abaco岛的3种抗菊科植物进行了植物化学分析。紫杉以桦木酸为主要成分，并含有大量的羽扇豆酚。紫锥菊中含有β-谷甾醇，桦木酸和巴比那维酸。巴氏烟草（Tabebuia bahamensis）含有大量的熊果酸。桦木酸可显着抑制亚马逊乳杆菌的前鞭毛体，但对小鼠巨噬细胞也有毒性。羽扇豆酚和桦木酸不显示抗菌活性，而β-谷甾醇强烈抑制黑曲霉。巴比那维酸对蜡状芽孢杆菌具有良好的抑制作用。熊果酸对MCF-7癌细胞非常活跃，并显着抑制金黄色葡萄球菌。 R. phylladenia和T. bahamensis分别是具有重要药用价值的桦木酸和熊果酸的主要来源。

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作者
Shrestha, Samon.;
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作者单位

The University of Alabama in Huntsville.;

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授予单位 The University of Alabama in Huntsville.;
学科 Analytical chemistry.;Molecular chemistry.;Organic chemistry.
学位 M.S.
年度 2015
页码 150 p.
总页数 150
原文格式 PDF
正文语种 eng
中图分类 TS97-4;
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6. Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants [O] . Hironori Tsuchiya 2015

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7. Phytochemical Analysis and Antileishmanial Activity of Clerodendrum myricoides and Salvadora persica Plant Extracts against Leishmania major [O] . Esther N. M. Maina, Virginia N. Njau, Yahaya Gavamukulya 2020

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8. Drug Development and Conservation of Biodiversity in West and Central Africa: Performance of Neurochemical and Radio Receptor Assays of Plant Extracts Drug Discovery for the Central Nervous System [R] . Efange, S. , Mash, D. C. 2004

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Phytochemical analysis of antileishmanial plants: A drug discovery approach.

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