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Comparative study of molecular changes in ovarian tumor progression and the identification of biomarkers.

机译：卵巢肿瘤进展中分子变化的比较研究和生物标志物的鉴定。

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摘要

Ovarian cancer is the fourth most common cause of cancer death among women. Approximately 75% of all cases are diagnosed at advanced stages, reflecting both the asymptomatic nature of the disease and the absence of reliable biomarkers for early detection. Ovarian adenocarcinomas commonly have a poor prognosis. The majority of ovarian tumors (~80%) are derived from the ovarian surface epithelial tissue with the most common histological subtypes being serous and mucinous. Epithelial ovarian tumors can be further subdivided into benign, borderline tumor and carcinoma reflective of their possible outcome.;Approximately 80% of individuals with borderline ovarian tumors (BTs) carry a favorable prognosis, as do individuals diagnosed with early stage ovarian carcinoma. However, there is a small percentage of BTs that eventually progress to carcinomas and subsequent poor prognosis. Unfortunately, favorable and poor prognosis BTs cannot be distinguished histologically. In an effort to identify potential biomarkers and to further understand the etiology and biology of cancer, we performed mRNA expression and DNA copy number profiling (array-comparative genomic hybridization (array-CGH)) on a well characterized set of BTs, primary adenocarcinomas and paired metastatic tumors. The integration of these two independent methods, mRNA pathway expression and array CGH profiling, confirmed the possible involvement of several novel molecular pathways in the development and progression of ovarian cancer.;Finally as a result of the analysis of the different pathways and chromosomal aberrations in primary adenocarcinomas and metastases of adenocarcinomas, we have identified new potential molecular biomarkers that could assist in the diagnosis, prognosis and determination of therapeutic strategies for ovarian cancer. The resulting molecular profiles not only clearly distinguished each histological tumor type but were also predictive of outcome in BTs.
机译：卵巢癌是女性中第四大最常见的癌症死亡原因。所有病例中约有75％被诊断为晚期，反映出该疾病的无症状性和缺乏早期检测的可靠生物标志物。卵巢腺癌通常预后较差。大部分卵巢肿瘤（约80％）都来自卵巢表面上皮组织，最常见的组织学亚型为浆液性和粘液性。上皮性卵巢肿瘤可进一步细分为良性，交界性肿瘤和癌，以反映其可能的结果。约有80％的交界性卵巢肿瘤（BTs）患者和诊断为早期卵巢癌的患者预后良好。但是，仅有少量的BT最终发展为癌和随后的不良预后。不幸的是，无法从组织学上区分预后良好和不良的BTs。为了确定潜在的生物标志物并进一步了解癌症的病因和生物学，我们对一组特征明确的BT，原发性腺癌和腺癌进行了mRNA表达和DNA拷贝数分析（阵列比较基因组杂交（array-CGH））。配对的转移性肿瘤。两种独立方法的整合，即mRNA途径表达和阵列CGH谱分析，证实了几种新的分子途径可能参与了卵巢癌的发展和进程。最后，通过分析不同途径和染色体畸变的结果原发性腺癌和腺癌的转移，我们已经确定了新的潜在分子生物标志物，可以帮助诊断，预后和确定卵巢癌的治疗策略。产生的分子图谱不仅清楚地区分了每种组织学肿瘤类型，而且还预测了BTs的预后。

著录项

  • 作者

    Cherry, James Michael.;

  • 作者单位

    The Catholic University of America.;

  • 授予单位 The Catholic University of America.;
  • 学科 Biology Molecular.;Biology Genetics.;Biology Cell.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 185 p.
  • 总页数 185
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子遗传学;遗传学;细胞生物学;
  • 关键词

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