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Synthesis and intermediate/by-product analysis of bromo-dragonfly, a dihydrobenzofuran analogue of phenethylamine hallucinogens.

机译：溴蜻蜓（苯乙胺致幻剂的二氢苯并呋喃类似物）的合成及中间产物/副产物分析。

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摘要

In 1998 and 2001, two articles were published by the Nichols lab (Purdue University) providing the synthesis for (R)-(-)-1-(8-Bromobenzo[1,2-b;4,5-b ']difuran-4-yl)-2-aminopropane hydrochloride (bromo-dragonfly). Since that time, bromo-dragonfly has become a much discussed topic in the drug community, with both users and analysts alike. Fairly pure samples of bromo-dragonfly have been found world-wide, with the one documented sample within the United States being found in Oregon. These samples have investigators wondering when the first clandestine lab will be found. It is also possible that illicit production and use of bromo-dragonfly has been overlooked due to the lack of availability of a synthesized chemical standard for comparison purposes. There is currently no chemical library available for the intermediates, by-products, and waste accrued in the bromo-dragonfly synthesis. This paper discusses the full synthesis of bromo-dragonfly following the method published in 2001. Synthetic methods were also modified and alternate approaches used in an attempt to optimize the synthesis. A library was created at the Sacramento County District Attorney's Laboratory of Forensic Services, compiling GC-MS data for each step. This synthesis is difficult and time-consuming, requiring sophisticated equipment and knowledge as well as liters of solvent and many toxic, atmosphere sensitive reagents. It is evident that the synthesis of bromo-dragonfly is far out of the capabilities of the typical clandestine chemist and lab. From the current research it can be concluded that only experienced and sophisticated chemists would be capable of accomplishing bromo-dragonfly synthesis and that only an established chemistry lab would be capable of producing samples of the caliber that have been documented to date.
机译：在1998年和2001年，Nichols实验室（普渡大学）发表了两篇文章，提供了（R）-（-）-1-（8-溴苯并[1,2-b; 4,5-b']二呋喃的合成方法-4-基）-2-氨基丙烷盐酸盐（溴蜻蜓）。从那时起，溴蜻蜓已成为药物界中讨论最多的话题，使用者和分析人员均如此。在世界范围内发现了相当纯净的溴蜻蜓样本，而在美国俄勒冈州发现了一个有据可查的样本。这些样本使调查人员想知道何时才能找到第一个秘密实验室。由于缺乏用于比较目的的合成化学标准品，也有可能忽视了蜻蜓蜻蜓的非法生产和使用。目前，尚无有关溴-蜻蜓合成中产生的中间体，副产物和废物的化学库。本文按照2001年发布的方法讨论了溴蜻蜓的完整合成方法。还对合成方法进行了修改，并尝试使用其他方法来优化合成方法。在萨克拉曼多县地方检察官法证服务实验室创建了一个库，为每个步骤收集GC-MS数据。这种合成是困难且费时的，需要复杂的设备和知识以及公升的溶剂和许多对大气有毒的试剂。显然，溴蜻蜓的合成远远超出了典型的秘密化学家和实验室的能力。从目前的研究可以得出结论，只有经验丰富的高级化学家才能完成溴-蜻蜓的合成，只有成熟的化学实验室才能生产迄今为止已记录的口径样品。

著录项

  • 作者

    Huntington, Brittany Christine.;

  • 作者单位

    University of California, Davis.;

  • 授予单位 University of California, Davis.;
  • 学科 Chemistry Analytical.;Chemistry Organic.
  • 学位 M.S.
  • 年度 2009
  • 页码 69 p.
  • 总页数 69
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;有机化学;
  • 关键词

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