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首页> 外文学位 >The Role of Tunneling Nanotubes in Mediating Intercellular Communication in Cancer.
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The Role of Tunneling Nanotubes in Mediating Intercellular Communication in Cancer.

机译：隧穿纳米管在介导癌症细胞间通讯中的作用。

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摘要

Tumors are highly heterogeneous entities composed of malignant and stromal cells functioning together as an invasive unit. Effective and efficient intercellular crosstalk in the three-dimensional complex tumor microenvironment is essential for cancer progression. A relatively new mechanism of intercellular communication has been identified in the form of a unique cellular protrusion called tunneling nanotubes (TNTs). TNTs are ultrafine (50--800 nm in diameter), long, non-adherent filamentous actin-based protrusions of the plasma membrane that can serve as intercellular bridges. They can aid in the sharing of proteins, genes, and other cargo between cells. In cancer, TNTs are particularly prevalent and have been shown to facilitate cargo transfer in tumors in vitro and in vivo, but their ultimate role in cancer progression remains unclear. The overall goal of this doctoral thesis work was to investigate the role of TNTs in the context of tumor heterogeneity, tumor metastasis, resistance to chemotherapeutic drugs, and the ability of TNT-mediated communication in conditions such as hypoxia that are typical of the tumor microenvironment. If intercellular communication via TNTs proves to be critical to tumor invasion and the development of treatment-resistance, then preventing or disrupting this communication mechanism represents a potential novel therapeutic strategy for treating cancers.
机译：肿瘤是高度异质的实体，由恶性和间质细胞共同充当侵入单元。在三维复杂肿瘤微环境中有效而高效的细胞间串扰对癌症进展至关重要。已经以称为隧道纳米管（TNT）的独特细胞突起的形式鉴定了相对较新的细胞间通讯机制。 TNT是超细的（直径50--800 nm），是质膜的长的，非粘附的，基于丝状肌动蛋白的突起，可以用作细胞间桥。它们可以帮助细胞之间共享蛋白质，基因和其他物质。在癌症中，TNT特别普遍，并已显示出可促进体内外肿瘤在体内的货物转运，但它们在癌症进展中的最终作用仍不清楚。这项博士论文的总体目标是研究TNT在肿瘤异质性，肿瘤转移，对化疗药物的耐药性以及TNT介导的在低氧等典型的肿瘤微环境条件下的沟通能力中的作用。 。如果事实证明经由TNT的细胞间通讯对肿瘤侵袭和抗药性的发展至关重要，那么预防或破坏这种通讯机制就代表了一种潜在的新型癌症治疗策略。

著录项

  • 作者

    Desir, Snider.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Cellular biology.;Biology.;Oncology.
  • 学位 Ph.D.
  • 年度 2018
  • 页码 157 p.
  • 总页数 157
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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