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Novel Polymer Composite Materials and Stimulation Devices for Bone Tissue Engineering Applications

机译：用于骨组织工程应用的新型聚合物复合材料和刺激装置

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摘要

Tissue engineering is a promising therapeutic approach to treat large tissue defects, addressing the challenges of limited tissue sources or potential host rejection in traditional treatment methods such as autograft and allograft. To obtain engineered tissues with ideal physiological conditions, two components are crucial for the tissue regeneration process: scaffold materials and biomimetic stimuli. Each of these components and their interactions have a significant impact on the functionality of engineered tissues.;In this dissertation, from a materials science and engineering aspect, advances in the development of functional scaffold materials and novel stimulation devices were performed. Relevant mechanisms of the interactions between the developed materials, or devices, with biological responses were also systematically studied.;In the first part of this dissertation, a high-throughput, low-cost, industrial-scale fabrication method was developed to produce a series of multi-functional polymer composites as scaffold materials for tissue engineering applications. With the inclusion of newly synthesized multi-functional additives, the produced polymer composites exhibited excellent osteogenic inducibility to human adipose-derived stem cells and satisfactory antibacterial efficiency against both E. coli and S. aureus. Relative to previously reported methods of direct loading silver nanoparticles into polymeric materials, the developed composites exhibited significantly reduced silver associated cytotoxicity. Also, a novel synergistic antibacterial effect at the material interface was found on the fabricated polymer composite, where the material exhibited significantly lower affinity to bacterial adhesion.;In the second part of this dissertation, a novel electrical field stimulation device was developed. The micro-fabricated stimulation device consists of micro-sized interdigitated electrodes, which provide a stable and consistent electric field above the surface. This configuration ensures the generation of a physiologically relevant electric field, even with application of ultra-low electric voltages, eliminating potential adverse electrochemical effects. Polymers were also coated onto the surface of the electrodes to further improve the biocompatibility of the stimulation device.;In summary, this dissertation successfully demonstrated the potential of applying industrial polymer processing technologies as a promising alternative approach to produce specially functionalized scaffolds for tissue engineering and regenerative medicine applications. The developed electrical field stimulation device provides manipulation and activation methods for stem cells that can be used without immunogenic bio-agents or complicated equipment.
机译：组织工程是治疗大型组织缺损的有前途的治疗方法，可解决传统自体移植和同种异体移植等传统治疗方法中组织来源有限或宿主排斥的挑战。为了获得具有理想生理条件的工程组织，两个组成部分对于组织再生过程至关重要：支架材料和仿生刺激。这些成分中的每一个及其相互作用对工程组织的功能都有重要影响。本论文从材料科学和工程学的角度，研究了功能支架材料和新型刺激装置的开发进展。还系统地研究了所开发的材料或装置之间的相互作用与生物反应的相关机理。;在本论文的第一部分，开发了一种高通量，低成本，工业规模的制造方法以生产一系列多功能聚合物复合材料作为组织工程应用的支架材料。通过加入新合成的多功能添加剂，制得的聚合物复合材料对人脂肪来源的干细胞表现出优异的成骨诱导性，并对大肠杆菌和金黄色葡萄球菌均具有令人满意的抗菌效果。相对于先前报道的将银纳米颗粒直接加载到聚合物材料中的方法，开发的复合材料表现出显着降低的银相关细胞毒性。此外，在所制备的聚合物复合材料上，在材料界面处发现了一种新型的协同抗菌作用，该材料对细菌粘附的亲和力明显较低。在本论文的第二部分，开发了一种新型的电场刺激装置。微型刺激装置由微型指状电极组成，可在表面上方提供稳定且一致的电场。即使施加超低电压，该配置也可确保产生生理相关的电场，从而消除了潜在的不利电化学效应。聚合物也被涂覆在电极表面上，以进一步改善刺激装置的生物相容性。总之，本文成功证明了应用工业聚合物加工技术作为生产用于组织工程和生物医学的特殊功能化支架的有前途的替代方法的潜力。再生医学的应用。研发的电场刺激设备为干细胞提供了操纵和激活方法，无需免疫原性生物试剂或复杂设备即可使用。

著录项

  • 作者

    Cai, Shaobo.;

  • 作者单位

    North Carolina State University.;

  • 授予单位 North Carolina State University.;
  • 学科 Materials science.;Biomedical engineering.;Textile research.
  • 学位 Ph.D.
  • 年度 2018
  • 页码 178 p.
  • 总页数 178
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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