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首页> 美国卫生研究院文献>Polymers >Development of Polymeric Nanocomposite (Xyloglucan-co-Methacrylic Acid/Hydroxyapatite/SiO2) Scaffold for Bone Tissue Engineering Applications—In-Vitro Antibacterial Cytotoxicity and Cell Culture Evaluation
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Development of Polymeric Nanocomposite (Xyloglucan-co-Methacrylic Acid/Hydroxyapatite/SiO2) Scaffold for Bone Tissue Engineering Applications—In-Vitro Antibacterial Cytotoxicity and Cell Culture Evaluation

机译：用于骨组织工程应用的聚合物纳米复合材料（木葡聚糖-共-甲基丙烯酸/羟磷灰石/ SiO2）支架的开发-体外抗菌细胞毒性和细胞培养评估

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Advancement and innovation in bone regeneration, specifically polymeric composite scaffolds, are of high significance for the treatment of bone defects. Xyloglucan (XG) is a polysaccharide biopolymer having a wide variety of regenerative tissue therapeutic applications due to its biocompatibility, in-vitro degradation and cytocompatibility. Current research is focused on the fabrication of polymeric bioactive scaffolds by freeze drying method for nanocomposite materials. The nanocomposite materials have been synthesized from free radical polymerization using n-SiO and n-HAp XG and Methacrylic acid (MAAc). Functional group analysis, crystallinity and surface morphology were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM) techniques, respectively. These bioactive polymeric scaffolds presented interconnected and well-organized porous morphology, controlled precisely by substantial ratios of n-SiO . The swelling analysis was also performed in different media at varying temperatures (27, 37 and 47 °C) and the mechanical behavior of the dried scaffolds is also investigated. Antibacterial activities of these scaffolds were conducted against pathogenic gram-positive and gram-negative bacteria. Besides, the biological behavior of these scaffolds was evaluated by the Neutral Red dye assay against the cell line. The scaffolds showed interesting properties for bone tissue engineering, including porosity with substantial mechanical strength, biodegradability, biocompatibility and cytocompatibility behavior. The reported polymeric bioactive scaffolds can be aspirant biomaterials for bone tissue engineering to regenerate defecated bone.
机译：骨再生，特别是聚合物复合支架的发展和创新对骨缺损的治疗具有重要意义。木葡聚糖（XG）是一种多糖生物聚合物，由于其生物相容性，体外降解和细胞相容性而具有广泛的再生组织治疗应用。当前的研究集中在通过冷冻干燥法制备用于纳米复合材料的聚合物生物活性支架。纳米复合材料是使用n-SiO和n-HAp XG和甲基丙烯酸（MAAc）通过自由基聚合合成的。分别通过傅里叶变换红外光谱（FTIR），X射线衍射分析（XRD）和扫描电子显微镜（SEM）技术研究了官能团分析，结晶度和表面形态。这些生物活性聚合物支架呈现出相互连接且组织良好的多孔形态，可通过n-SiO的实质比例精确控制。溶胀分析也在不同的温度（27、37和47°C）下在不同的介质中进行，还研究了干燥脚手架的机械性能。这些支架对致病性革兰氏阳性和革兰氏阴性细菌的抗菌活性。此外，通过对细胞系的中性红染料分析评估了这些支架的生物学行为。支架对骨组织工程显示出令人感兴趣的性质，包括具有实质性机械强度的孔隙率，生物降解性，生物相容性和细胞相容性行为。报道的聚合物生物活性支架可以是用于骨组织工程以再生排便的骨的有希望的生物材料。

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