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Characterization of the Interaction between Candida albicans and Streptococcus mutans.

机译：白色念珠菌和变形链球菌之间的相互作用的表征。

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摘要

The oral microbial communities are some of the most complex microbial floras in the human body. Occurrence of oral disease results from disturbance of the equilibrium of this ecosystem. Dental caries or tooth decay is the most common oral disease particularly in children characterized by irreversible destruction of the tooth mediated by demineralization of dental surfaces. These processes are the result of interactions between the various microbial species embedded in the biofilm formed on tooth surface known as dental plaque. These complex interactions between metabolically active microbial species cause fluctuations in pH ultimately resulting in dissolution of the dental hard tissues and formation of carious lesions. The bacterial species Streptococcus mutans has long been considered the etiologic agent of caries, however recent in vitro evidence seem to indicate a role for the fungal species Candida albicans in mediating cariogenic development via its physical and metabolic interactions with S. mutans. However, in depth investigations are required to determine mechanistically precise details of adhesion and signaling under conditions of co-existence. To that end, the goal of this proposal is to characterize the interaction between C. albicans and S. mutans using biologically relevant in vitro model systems. Specifically, we aim to demonstrate that the strong co-adherence of these diverse oral pathogens to each other and to oral surfaces results in the formation of mature biofilms, a pre-requisite for the development of dental caries. Importantly, as design of effective therapies to treat caries has been a challenge, this project also aimed to develop a novel antimicrobial bioadhesive hydrogel formulation for use as oral topical agent with targeted action geared towards blocking microbial adhesion to surfaces and in turn prevention and eradication of biofilms. The accomplishment of the work proposed in this project will provide crucial insights into the potential role of C. albicans in the development of dental caries, an area of research that is yet to be explored. The ultimate goal is to contribute to our understanding of the various factors and conditions that play a role in microbial colonization and the progression of colonization to infection. Such crucial information will have important clinical implications as it aids in the identification and the design of novel therapeutic strategies aimed at the prevention and/or treatment of dental caries and oral infections in general. Significantly, the novel findings generated strongly indicate that the presence of C. albicans in the oral environment should be considered as an additional factor in evaluating risks of caries.
机译：口腔微生物群落是人体中一些最复杂的微生物菌群。口腔疾病的发生是由于该生态系统平衡的破坏。龋齿或蛀牙是最常见的口腔疾病，尤其是在儿童中，其特征是由牙齿表面的脱矿质介导的牙齿不可逆破坏。这些过程是嵌入在被称为牙菌斑的牙齿表面上形成的生物膜中的各种微生物之间相互作用的结果。代谢活性微生物之间的这些复杂的相互作用导致pH值的波动，最终导致牙齿硬组织的溶解和龋齿的形成。细菌变形链球菌一直被认为是龋齿的病原体，但是最近的体外证据似乎表明，真菌白色念珠菌通过其与变形链球菌的物理和代谢相互作用介导了龋齿的发生。但是，需要进行深入研究以确定在共存条件下粘附和发信号的机械精确细节。为此，该建议的目的是使用生物学相关的体外模型系统表征白色念珠菌和变形链球菌之间的相互作用。具体而言，我们旨在证明这些多样的口腔病原体彼此之间以及与口腔表面之间的强共粘附性导致形成成熟的生物膜，这是龋齿发展的先决条件。重要的是，由于设计有效的治疗龋齿的方法一直是一个挑战，该项目还旨在开发一种新型的抗菌生物粘附水凝胶制剂，用作口服局部用药，其靶向作用旨在阻断微生物与表面的粘附，进而预防和根除细菌。生物膜。该项目中提出的工作的完成将提供关于白色念珠菌在龋齿发展中潜在作用的重要见解，这一领域尚待探索。最终目的是帮助我们理解在微生物定植和定植向感染进展中起作用的各种因素和条件。这些关键信息将具有重要的临床意义，因为它有助于识别和设计旨在预防和/或治疗一般龋齿和口腔感染的新型治疗策略。重要的是，产生的新发现强烈表明，口腔环境中存在白色念珠菌应被视为评估龋齿风险的另一个因素。

著录项

  • 作者

    Mutawalli, Khalid Hassan.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Biology Microbiology.;Health Sciences Dentistry.
  • 学位 M.S.
  • 年度 2014
  • 页码 69 p.
  • 总页数 69
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

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