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首页> 外文期刊>Molecular oral microbiology >Antigen I/II mediates interactions between Streptococcus mutans Streptococcus mutans and Candida albicans Candida albicans
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Antigen I/II mediates interactions between Streptococcus mutans Streptococcus mutans and Candida albicans Candida albicans

机译：抗原I / II介导链球菌细胞链球菌和念珠菌念珠菌念珠菌念珠菌的相互作用

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摘要

Streptococcus mutans and Candida albicans are frequently co‐isolated from dental plaque of children with early childhood caries ( ECC ) and are only rarely found in children without ECC , suggesting that these species interact in a manner that contributes to the pathogenesis of ECC . Previous studies have demonstrated that glucans produced by S.?mutans are crucial for promoting the formation of biofilm and cariogenicity with C.?albicans ; however, it is unclear how non‐glucan S.?mutans biofilm factors contribute to increased biofilm formation in the presence of C.?albicans . In this study we examined the role of S.?mutans antigen I/II in two‐species biofilms with C.?albicans , and determined that antigen I/II is important for the incorporation of C.?albicans into the two‐species biofilm and is also required for increased acid production. The interaction is independent of the proteins Als1 and Als3, which are known streptococcal receptors of C.?albicans . Moreover, antigen I/ II is required for the colonization of both S.?mutans and C.?albicans during co‐infection of Drosophila melanogaster in vivo. Taken together, these results demonstrate that antigen I/ II mediates the increase of C.?albicans numbers and acid production in the two‐species biofilm, representing new activities associated with this known S.?mutans adhesin.
机译：链球菌异常和念珠菌常常与早期儿童龋病（ECC）的牙科斑块共同分离，并且在没有ECC的儿童中只能在儿童中发现，这表明这些物种以有助于ECC发病机制的方式相互作用。以前的研究表明，由S.?培养物产生的葡聚糖对于促进生物膜和致癌性的葡聚糖是至关重要的。然而，目前尚不清楚非葡聚糖S.?培养物生物膜因子如何在C.? albicans存在下增加生物膜形成。在这项研究中，我们研究了S.?mutans抗原I / II的作用，用C.? albicans，并确定抗原I / II对C.? albicans掺入两种物种生物膜是重要的并且还需要增加酸生产。相互作用与蛋白质ALS1和ALS3无关，蛋白质ALS1和ALS3是已知的C.? albicans的链球菌受体。此外，抗原I / II在体内果蝇黑素体的共同感染期间，抗原I / II.S染色。总之，这些结果表明，抗原I / II在两种生物膜中介导C.? albicans数量和酸产生的增加，代表与该已知的S.Omutans粘附蛋白相关的新活动。

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  • 来源
    《Molecular oral microbiology》 |2018年第4期|共9页
  • 作者

    Yang C.; Scoffield J.; Wu R.; Deivanayagam C.; Zou J.; Wu H.;

  • 作者单位

    Department of Pediatric DentistryUniversity of Alabama at BirminghamBirmingham AL USA;

    Department of Pediatric DentistryUniversity of Alabama at BirminghamBirmingham AL USA;

    Department of Pediatric DentistryUniversity of Alabama at BirminghamBirmingham AL USA;

    Department of Biochemistry and Molecular GeneticsUniversity of Alabama at BirminghamBirmingham AL;

    Department of Pediatric DentistryWest China Hospital of StomatologyChengdu China;

    Department of Pediatric DentistryUniversity of Alabama at BirminghamBirmingham AL USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

    antigen I/ II; Candida albicans; early childhood caries; Streptococcus mutans;

    机译：抗原I / II;念珠菌蛋白质龋;幼儿龋;链球菌变异;

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