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首页> 外文学位 >Prevention of heterologous Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection using an antibody-virus complex vaccine.
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Prevention of heterologous Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection using an antibody-virus complex vaccine.

机译：使用抗体-病毒复合疫苗预防异源猪繁殖与呼吸综合症病毒（PRRSv）感染。

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摘要

Porcine Reproductive and Respiratory Syndrome virus (PRRSv) continues to cause critical issues for the swine industry worldwide, with an estimated loss of ;We present efficacy of preliminary and primary vaccine trials utilizing antibody-virus complex (Ab-virus) vaccines in prevention of homologous and heterologous PRRSv infection through assessment of viral loads as determined by real-time polymerase chain reaction and PRRSv associated pathology in the lung. Additionally, we determined the safety and immunogenicity of the Ab-virus complex. Antibody-virus complex vaccines were compared to autogenous and commercially available PRRSv vaccines. An initial study utilizing Ab-virus complex vaccine and heterologous challenge, Ab-virus vaccinees developed Nab towards the vaccine and challenge strains earlier than controls and had reduced pulmonary pathology.;The primary vaccine trial demonstrated that a single Ab-virus complex vaccination was effective in preventing heterologous infection in thirty-three percent of vaccinees compared to only ten percent of pigs receiving autogenous vaccine. Vaccines did not make pigs ill. Ab-virus complex vaccinees not protected from infection following heterologous challenge, had marked reduction in viremia as compared to autogenous and unvaccinated controls. Vaccinees that became infected, had significant reduction in pulmonary viral loads which was reflective of reduced pulmonary pathology. Future studies building on this research involve determination of the breadth of cross-protection afforded with these novel vaccines and the mechanism of immune refocusing.
机译：猪繁殖与呼吸综合症病毒（PRRSv）继续造成全球养猪业的关键问题，估计损失；我们目前利用抗体-病毒复合物（Ab-virus）疫苗预防同源性的初步和主要疫苗试验的功效通过评估病毒载量（通过实时聚合酶链反应和PRRSv相关的肺部病理学确定）来评估病毒和异源PRRSv感染。此外，我们确定了Ab病毒复合物的安全性和免疫原性。将抗体-病毒复合疫苗与自体和市售PRRSv疫苗进行了比较。最初使用Ab-病毒复合疫苗和异源攻击的研究，Ab-病毒疫苗比对照更早开发了针对该疫苗和攻击菌株的Nab，并降低了肺部病理学;主要疫苗试验表明，单次Ab-病毒复合疫苗接种是有效的在预防异源感染方面，有33％的疫苗接种，而只有10％的猪接受了自体疫苗。疫苗并未使猪患病。与自体和未接种疫苗的对照相比，未进行异源攻击后不能预防感染的Ab-病毒复合疫苗具有明显的病毒血症降低。被感染的疫苗可显着降低肺部病毒载量，这反映出肺部病理状况的减轻。基于这项研究的未来研究涉及确定这些新型疫苗提供的交叉保护的广度以及免疫重聚焦的机制。

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  • 作者

    Hemnani, Khushboo.;

  • 作者单位

    Iowa State University.;

  • 授予单位 Iowa State University.;
  • 学科 Virology.;Veterinary science.;Immunology.
  • 学位 M.S.
  • 年度 2014
  • 页码 85 p.
  • 总页数 85
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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