• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Methamphetamine absorption by skin oils: Accumulated mass, partition coefficients and the influence of fatty acids.
【24h】

Methamphetamine absorption by skin oils: Accumulated mass, partition coefficients and the influence of fatty acids.

机译：甲基苯丙胺被皮肤油吸收：累积质量，分配系数和脂肪酸的影响。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Occupants of former methamphetamine laboratories, often residences, may experience increased exposure through the accumulation of the methamphetamine in skin oil. The objectives of this study were to determine equilibrium partition coefficients of vapor-phase methamphetamine with artificial skin oil (ASO), artificial skin oil without fatty acids and real skin oil. A 10 L flow through stainless-steel chamber and in-line filter holders were used to expose skin-oil coated filters to vapor-phase methamphetamine at concentrations ranging from 12 ppb to 159 ppb and samples were analyzed for exposure time periods from 2 hours to 60 days. For a low vapor-phase methamphetamine concentration range of ~12-28 ppb, the equilibrium partition coefficient was 1499 +/- 195 microg meth/g SO/ppb. For a high concentration range of 98-159 ppb, the equilibrium partition coefficient was lower, 394 +/- 90.6 microg meth/g SO/ppb, suggesting some saturation of the available absorption capacity. The partition coefficient for artificial skin oil without fatty acids was 33 +/- 6 microg meth/g SO/ppb, much lower than any value measured in this study or a previous 60 day study that used real human skin oil in which an average mass normalized partition coefficient of 1410 +/- 840 microg meth/g SO/ppb was measured. We believe that the measured coefficients are much greater than the predicted value due to the presence of organic acids in the skin oil, which contribute protons, lower the pH and increase the capacity for basic organic compounds like methamphetamine. The very large absorption capacity suggests that surfaces covered in skin oils would accumulate methamphetamine to levels that exceed recommended surface remediation standards, even for air concentrations in the low part per trillion range.
机译：前甲基苯丙胺实验室的居民，经常是居民，可能会因皮肤油中甲基苯丙胺的积累而暴露增加。这项研究的目的是确定气相甲基苯丙胺与人造皮肤油（ASO），不含脂肪酸的人造皮肤油和真实皮肤油的平衡分配系数。通过不锈钢室和串联过滤器支架的10 L流量用于将涂有皮肤油的过滤器暴露于浓度为12 ppb至159 ppb的气相甲基苯丙胺，并分析样品的暴露时间2小时至60天对于〜12-28 ppb的低气相甲基苯丙胺浓度范围，平衡分配系数为1499 +/- 195 microg meth / g SO / ppb。对于98-159 ppb的高浓度范围，平衡分配系数较低，为394 +/- 90.6 microg meth / g SO / ppb，表明可用吸收能力有些饱和。不含脂肪酸的人造皮肤油的分配系数为33 +/- 6微克meth / g SO / ppb，远低于本研究或之前使用天然人类皮肤油（平均质量）的60天研究中测得的任何值测量的归一化分配系数为1410 +/- 840 microg meth / g SO / ppb。我们相信，由于皮肤油中存在有机酸，因此测得的系数远高于预测值，有机酸有助于质子，降低pH值并增加诸如甲基苯丙胺等碱性有机化合物的容量。极高的吸收能力表明，即使空气浓度在万亿分之几的较低范围内，皮肤油脂覆盖的表面也会累积甲基苯丙胺，其浓度超过建议的表面修复标准。

著录项

  • 作者

    Parker, Kristia.;

  • 作者单位

    Missouri University of Science and Technology.;

  • 授予单位 Missouri University of Science and Technology.;
  • 学科 Environmental engineering.
  • 学位 M.S.
  • 年度 2014
  • 页码 60 p.
  • 总页数 60
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号