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Magnetic resonance imaging and anthropometric measurements: A correlational study in fixed fetal specimens.

机译：磁共振成像和人体测量：固定胎儿标本的相关研究。

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摘要

For many decades the Boston University School of Medicine Department of Anatomy and Neurobiology has housed an unprovenienced collection of fetal specimens. At least ten percent of the 137 fetal specimens were lost due to drying out and other damage. The specimens were stored for many decades in individual fluid filled containers. There is no reliable information regarding the medical or curation histories of the human fetal specimens. Furthermore, there is concern that the fixative may have led some internal structures to shrink more than others. At issue was to determine whether the specimens had maintained or lost their relationships, and size amongst internal structures.;In normal fetal development the cerebellum, the femur, and the foot all follow mostly positive linear growth with age. Therefore, the purpose of the present study was to assess whether these specimens demonstrate anatomical correlations that one might find within in utero fetuses.;This prospective correlation study used MRI images of the cerebellum and femur as well as anthropometric measurements of each foot and mass to seek to answer this question. A blind, random sample of twenty-five specimens was selected from forty-eight specimens roughly grouped by size. The Boston University Institutional Review Board was notified and, assigned waiver status to the application because the specimens were unprovenienced fixed tissue.;All specimens were magnetic resonance scanned at the Center for Biomedical Imaging at the Boston University School of Medicine using a 3.0T whole body scanner (Achieva, Philips Healthcare, Best, The Netherlands). All scans were acquired using the 8-channel high-resolution head coil made by Invivo for the Achieva 3T scanner.;This study found that the measurements taken from the images, and the feet had good intra-rater reliability because paired t-tests did not show significant differences between the measurements (alpha (&agr;) 0.17, t-values were less than t-critical, and R 2 < 0.02).;Pearson's correlation coefficient testing revealed strong positive correlation between all the mean measures comparing these three structures: transverse cerebellar diameter (TCD), femur length, and foot length (&agr; 0.91, p 0.82). Leading us to conclude that the dimensions of the soft tissues - TCD; and bone tissues - femur and foot of the lower extremities were unlikely to have changed significantly in decades of storage.
机译：几十年来，波士顿大学医学院解剖与神经生物学系一直收藏着大量的胎儿标本。 137个胎儿标本中至少有百分之十是由于干燥和其他损坏而丢失的。标本在单独装满液体的容器中保存了数十年。没有关于人类胎儿标本的医学或治疗史的可靠信息。此外，担心固定剂可能导致某些内部结构比其他结构收缩更多。问题在于确定标本是否保持或失去了它们之间的关系以及内部结构之间的大小。在正常的胎儿发育中，小脑，股骨和脚随年龄的增长大多呈正线性增长。因此，本研究的目的是评估这些标本是否显示出可能在子宫内胎儿中发现的解剖学相关性;这项前瞻性相关性研究使用了小脑和股骨的MRI图像以及人体每只脚和肿块的人体测量结果。寻求回答这个问题。从按大小大致分组的48个样本中选择了25个样本的盲目随机样本。通知了波士顿大学机构审查委员会，并由于该标本是未经证实的固定组织而被授予豁免状态;所有标本均在波士顿大学医学院生物医学影像中心使用3.0T全身进行了磁共振扫描扫描仪（Achieva，Philips Healthcare，Best，荷兰）。所有扫描都是使用Invivo为Achieva 3T扫描仪制作的8通道高分辨率头线圈进行的;该研究发现，从图像中获取的测量值以及脚部均具有良好的评分内可靠性，因为配对t检验确实没有显示出测量之间的显着差异（α（agr）0.17，t值小于t临界，并且R 2 <0.02）。； Pearson相关系数测试显示，比较这三种结构的所有均值测量之间均存在强正相关：小脑横径（TCD），股骨长和脚长（α0.91，p 0.82）。导致我们得出以下结论：软组织的尺寸-TCD；和骨组织-股骨和下肢的脚在储存数十年后不太可能发生显着变化。

著录项

  • 作者

    Wickum, Mary Ellen.;

  • 作者单位

    Boston University.;

  • 授予单位 Boston University.;
  • 学科 Health Sciences Radiology.;Health Sciences Human Development.;Anthropology Medical and Forensic.
  • 学位 M.S.
  • 年度 2014
  • 页码 90 p.
  • 总页数 90
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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