首页> 外文学位 >Formation of 2-halomethylene-4-cyclopentene-1,3-diones and/or 2-halo-1,4-benzoquinones, total synthesis of methyl linderone and Wacker-type oxidation of aryl-substituted alkenes.

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Formation of 2-halomethylene-4-cyclopentene-1,3-diones and/or 2-halo-1,4-benzoquinones, total synthesis of methyl linderone and Wacker-type oxidation of aryl-substituted alkenes.

机译：形成2-卤代亚甲基-4-环戊烯-1,3-二酮和/或2-卤代-1,4-苯醌，甲基异戊二烯酮的全合成和芳基取代的烯烃的Wacker型氧化。

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We have discovered a practical general method for the preparation of diverse 2-halomethylene-4-cyclopentene-1,3-diones and/or 2-halo-1,4-benzoquinones. An in-depth study of the reactions of 4-(ethynyl)-4-hydroxy-2,3-substituted-2-cyclobuten-1-ones with N-bromo- or N-iodosuccinimide is described. This reaction was used in a short total synthesis of methyl linderone. Also, a series of facile, palladium catalyzed, direct, and regiospecific Wacker-type oxidations has been developed to yield various alpha-arylated ketones from aryl-substituted internal alkenes.

机译：我们已经发现了制备各种2-卤代亚甲基-4-环戊烯-1，3-二酮和/或2-卤代-1，4-苯醌的实用通用方法。描述了对4-（乙炔基）-4-羟基-2,3-取代的2-环丁烯-1-酮与N-溴代或N-碘代琥珀酰亚胺的反应的深入研究。该反应用于短时间的甲基邻苯二酚全合成。而且，已经开发出一系列容易的，钯催化的，直接的和区域特异性的Wacker型氧化，以从芳基取代的内部烯烃产生各种α-芳基化的酮。

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作者
Yin, Hong.;
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作者单位

West Virginia University.;

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授予单位 West Virginia University.;
学科 Chemistry Organic.
学位 Ph.D.
年度 2014
页码 252 p.
总页数 252
原文格式 PDF
正文语种 eng
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1. Formation of 2-halomethylene-4-cyclopentene-1,3-diones and/or 2-halo-1,4-benzoquinones via ring-expansion of 4-ethynyl-4-hydroxy-2,3- substituted-2-cyclobuten-1-ones. Total synthesis of methyl linderone [J] . Yin H., Dantale S.W., Akhmedov N.G., Tetrahedron . 2013,第44期

机译：通过4-乙炔基-4-羟基-2,3-取代的2-环丁烯-的扩环形成2-卤代亚甲基-4-环戊烯-1,3-二酮和/或2-卤代-1,4-苯醌1个全合成甲基linderone
2. Synthesis of Aryl-Substituted 1,4-Benzoquinone via Palladium(II)-Catalyzed Decarboxylative Coupling of Arene Carboxylate with 1,4-Benzoquinone [J] . Yankai Zhao, Yuexia Zhang, Jiantao Wang, Synlett . 2010,第15期

机译：钯（II）催化芳烃羧酸与1,4-苯醌的脱羧偶联合成芳基取代的1,4-苯醌
3. Synthesis of aryl-substituted 1,4-benzoquinone via water-promoted and In(OTf)(3)-catalyzed in situ conjugate addition-dehydrogenation of aromatic compounds to 1,4-benzoquinone in water [J] . Zhang HB, Liu L, Chen YJ, Advanced synthesis & catalysis . 2006,第1a2期

机译：通过水促进和In（OTf）（3）催化原位共轭加成-芳族化合物在水中加氢脱氢制芳基取代的1,4-苯醌
4. Synthesis of 2-methyl-5-methoxy-l,4-benzoquinone and In-silico Activity Profiling Toward Cytochrome P450-3A4 [C] . Fath Dwisari, Arie Srihardyastutie, Siti Mariyah Ulfa Annual Basic Science International Conference . 2019

机译：合成2-甲基-5-甲氧基-1,4-苯醌和硅活性分析的细胞色素P450-3A4
5. Part I: The first regio- and atropdiastereoselective total synthesis of the dimeric indole alkaloid (+)-dispegatrine, as well as the first total synthesis of the sarpagine alkaloids (+)-spegatrine, lochvinerine, (+)-lochneram and an improved total synthesis of (+)-10-methoxyvellosimine, (+)-lochnerine and (+)-sarpagine. Part II: Studies directed toward the total synthesis of the carbon-19 methyl substituted sarpagine-macroline alkaloids (+)-macro-salhine chloride as well as macrocarpine A, B and C. [D] . Edwankar, Chitra R. 2011

机译：第一部分：二聚吲哚生物碱（+）-dispegatrine的第一个区域和对映异构选择性全合成，以及sarpagine生物碱（+）-spegatrine，lochvinerine，（+）-lochneram的第一个全合成（+）-10-甲氧基玻璃素胺，（+）-氯精胺和（+）-sarpagine的合成。第二部分：研究碳19甲基取代的沙雷帕金-大麦碱生物碱（+）-大-沙丁鱼碱氯化物以及大芸香碱A，B和C的总合成。
6. Stereoselective Synthesis of cis-25-Disubstituted Pyrrolidines via Wacker-Type Aerobic Oxidative Cyclization of Alkenes with tBu-Sulfinamide Nucleophiles [O] . Joanne E. Redford, Richard I. McDonald, Matthew L. Rigsby, -1

机译：通过烯烃的瓦克型有氧氧化环化与TBU亚磺酰胺亲核试剂的顺式25-二取代的吡咯烷类的立体选择性合成
7. Nucleophilic alkenes. V. Formation of a naphthalenic system by addition of 1,1-Dimethoxyethene to 2-Acetyl-1,4-benzoquinone and subsequent transformation [O] . DW Cameron, GI Feutrill, MA Sefton 1978

机译：亲核烯烃。 V.通过加入1,1-二甲氧基乙烯至2-乙酰基-1,4-苯醌和随后的转化形成萘体系
8. One-Pot Synthesis of Aromatic Methyl Esters by Electrochemical Oxidation ofAldehydes Mediated by Biscoenzyme Catalysis [R] . Tam, S. W., Jimenez, L., Diederich, F. 1992

机译：Biscoenzyme催化醛电化学氧化一锅法合成芳香甲酯

Formation of 2-halomethylene-4-cyclopentene-1,3-diones and/or 2-halo-1,4-benzoquinones, total synthesis of methyl linderone and Wacker-type oxidation of aryl-substituted alkenes.

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