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Mapping myocardial elasticity with intracardiac acoustic radiation force impulse methods.

机译：用心内声辐射力脉冲法绘制心肌弹性。

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摘要

mplemented on an intracardiac echocardiography transducer, acoustic radiation force methods may provide a useful means of characterizing the heart's elastic properties. Elasticity imaging may be of benefit for diagnosis and characterization of infarction and heart failure, as well as for guidance of ablation therapy for the treatment of arrhythmias. This thesis tests the hypothesis that with appropriately designed imaging sequences, intracardiac acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) are viable tools for quantification of myocardial elasticity, both temporally and spatially. Multiple track location SWEI (MTL-SWEI) is used to show that, in healthy in vivo porcine ventricles, shear wave speeds follow the elasticity changes with contraction and relaxation of the myocardium, varying between 0.9 and 2.2 m/s in diastole and 2.6 and 5.1 m/s in systole. Infarcted tissue is less contractile following infarction, though not unilaterally stiffer. Single-track-location SWEI (STL-SWEI) is proven to provide suppression of speckle noise and enable improved resolution of structures smaller than 2 mm in diameter compared to ARFI and MTL-SWEI. Contrast to noise ratio and lateral edge resolution are shown to vary with selection of time step for ARFI and arrival time regression filter size for STL-SWEI and MTL-SWEI. In 1.5 mm targets, STL-SWEI achieves alternately the tightest resolution (0.3 mm at CNR = 3.5 for a 0.17 mm filter) and highest CNR (8.5 with edge width = 0.7 mm for a 0.66 mm filter) of the modalities, followed by ARFI and then MTL-SWEI. In larger, 6 mm targets, the CNR-resolution tradeoff curves for ARFI and STL-SWEI overlap for ARFI time steps up to 0.5 ms and kernels
机译：借助心脏内超声心动图换能器，声辐射力方法可提供表征心脏弹性特性的有用手段。弹性成像可能有益于梗死和心力衰竭的诊断和表征，以及用于治疗心律不齐的消融治疗的指导。本论文检验了以下假说：通过适当设计的成像序列，心内声辐射力脉冲（ARFI）成像和切波弹性成像（SWEI）是在时间和空间上量化心肌弹性的可行工具。多轨迹位置SWEI（MTL-SWEI）用于显示，在健康的体内猪心室中，剪切波速度跟随弹性随心肌收缩和松弛而变化，在舒张期为0.9到2.2 m / s，在2.6到2.6之间。收缩压为5.1 m / s。梗死后梗塞的组织收缩性较弱，尽管不是单方面变硬。与ARFI和MTL-SWEI相比，单轨定位SWEI（STL-SWEI）可以抑制斑点噪声，并可以提高直径小于2 mm的结构的分辨率。相对于ARFI的时间步长和STL-SWEI和MTL-SWEI的到达时间回归滤波器的大小，对比噪声比和横向边缘分辨率显示为变化。在1.5毫米目标中，STL-SWEI交替实现模式的最紧密分辨率（对于0.17毫米滤镜，CNR = 3.5毫米= 3.5毫米）和最高CNR（对于0.66毫米滤镜，CNR 8.5最高，边缘宽度= 0.7毫米），其次是ARFI然后是MTL-SWEI。在较大的6毫米目标中，ARFI和STL-SWEI的CNR分辨率权衡曲线在ARFI时间步长达0.5 ms和内核时重叠

著录项

  • 作者

    Hollender, Peter J.;

  • 作者单位

    Duke University.;

  • 授予单位 Duke University.;
  • 学科 Biomedical engineering.;Medical imaging.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 303 p.
  • 总页数 303
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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