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首页> 外文学位 >Functional and structural brain markers of the genetic vulnerability to schizophrenia: A neuroimaging investigation of schizophrenia patients, non -psychotic adult relatives, and community ontrols.
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Functional and structural brain markers of the genetic vulnerability to schizophrenia: A neuroimaging investigation of schizophrenia patients, non -psychotic adult relatives, and community ontrols.

机译：精神分裂症遗传易感性的功能性和结构性脑标志物：对精神分裂症患者，非精神病成年亲属和社区存在的神经影像学调查。

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摘要

Diffuse functional and structural brain abnormalities are commonly found in schizophrenia patients and are reported in patients' first-degree non-psychotic relatives. Previously, investigators have reported functional and structural abnormalities in the prefrontal and parietal cortices of schizophrenia patients and non-psychotic relatives compared to controls. The goal of the present study was to recruit a new sample of schizophrenia patients, non-psychotic relatives, and community controls to investigate in tandem, functional and structural correlates of the schizophrenia diathesis at varying genetic loads. Imaging data were collected on 27 patients, 23 non-psychotic relatives, and 36 controls. Functional imaging was conducted during a context processing task that required the active suppression of an automatic tendency to complete a weaker task-relevant response. Analysis of behavioral data demonstrated all groups had more difficulty overriding an automatic response evidenced by longer mean reaction times on these trials compared to automatic response trials. Schizophrenia patients demonstrated more difficulty inhibiting automatic responses than completing an automatic response compared to relatives and controls. Schizophrenia patients and relatives demonstrated less activity than controls during maintenance of context-related information in the left inferior prefrontal region (BA 45/46). In addition structurally, schizophrenia patients demonstrated thinner superior frontal, inferior parietal, and supramarginal regions compared to controls and relatives. Impairments associated with the genetic vulnerability to schizophrenia in this sample were the greatest when neural correlates were taxed using a cognitive paradigm and measured directly using fMRI.
机译：弥散性功能和结构性脑异常通常在精神分裂症患者中发现，并在患者的一级非精神病亲属中报告。以前，研究者已经报告了精神分裂症患者和非精神病亲戚与对照组相比前额叶和顶叶皮层的功能和结构异常。本研究的目的是招募新的精神分裂症患者，非精神病亲戚和社区控制的样本，以研究在不同遗传负荷下精神分裂症素质的串联，功能和结构相关性。收集了27位患者，23位非精神病亲戚和36位对照的影像数据。功能成像是在上下文处理任务期间进行的，该任务需要主动抑制自动趋势以完成较弱的任务相关响应。行为数据分析表明，与自动应答试验相比，这些试验的平均反应时间更长，所有组都难以克服自动应答。与亲戚和对照组相比，精神分裂症患者表现出比完成自动应答更大的困难。维持左下额叶前额叶区域中与情境相关的信息期间，精神分裂症患者和亲属的活动少于对照组（BA 45/46）。此外，与对照组和亲属相比，精神分裂症患者的额叶上部，顶下壁和臀上肌区域更薄。当使用认知范式对神经相关性征税并使用fMRI直接测量时，该样本中与精神分裂症的遗传脆弱性相关的损害最大。

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  • 作者

    Goghari, Vina Mahesh.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Clinical psychology.;Genetics.;Mental health.;Cognitive psychology.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 112 p.
  • 总页数 112
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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