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Genetic variations in three interacting single nucleotide polymorphisms and the risk of preterm birth in Black families.

机译：黑人家庭中三个相互作用的单核苷酸多态性的遗传变异和早产风险。

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摘要

Preterm birth, defined as birth prior to 37 completed weeks gestation, is a serious health concern. Despite advances in health care screening and interventions, the rate of preterm birth in the United States has risen more than 30 percent since 1981. In 2006, Menon and associates reported the first multilocus genetic interaction in three single nucleotide polymorphisms predictive of spontaneous preterm birth in a population of White mothers. A gene association study using a case-control design was conducted to determine whether the results of the Menon study were also true for Black women and their infants. The case group included 22 preterm mothers and 22 preterm infants. The control group included 106 term mothers and 108 term infants. Study variables included high-risk and low-risk genetic combinations of the three single nucleotide polymorphisms. Birth certificate applications were reviewed to determine subject eligibility. Blood samples obtained by hospital personnel were sent to a laboratory for genotyping. It was predicted that there would be no statistically significant difference in the occurrence of the high-risk genetic patterns in the preterm Black mothers or their infants. Data analysis suggested that the multilocus genetic combinations reported by Menon were not predictors for preterm birth in Black mothers or their infants. Further study is recommended to identify genetic variations predictive of preterm birth across ethnic groups.
机译：早产定义为严重的健康问题，早产是指在妊娠37周之前出生的早产。尽管医疗保健筛查和干预措施取得了进步，但美国早产率自1981年以来已经增长了30％以上。2006年，Menon及其同事报道了预测自发性早产的三种单核苷酸多态性中的首次多基因遗传相互作用。一群白人母亲。进行了使用病例对照设计的基因关联研究，以确定Menon研究的结果是否也适用于黑人妇女及其婴儿。病例组包括22名早产母亲和22名早产婴儿。对照组包括106个足月母亲和108个足月婴儿。研究变量包括三种单核苷酸多态性的高风险和低风险遗传组合。对出生证明申请进行了审查，以确定受试者的资格。医院人员采集的血液样本被送至实验室进行基因分型。预计在早产黑人母亲或其婴儿中，高风险遗传模式的发生在统计上不会有显着差异。数据分析表明，梅农报告的多基因座遗传组合不能预测黑人母亲或其婴儿的早产。建议进行进一步的研究，以鉴定可预测不同种族早产的遗传变异。

著录项

  • 作者

    Steinbach, Margaret.;

  • 作者单位

    University of Miami.;

  • 授予单位 University of Miami.;
  • 学科 Nursing.;Black studies.;Obstetrics.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 124 p.
  • 总页数 124
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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