首页> 外文学位 >High resolution DNA copy number analysis of supratentorial primitive neuroectodermal tumours indicates frequent alterations in the cadherin-catenin adhesion pathway.

【24h】

High resolution DNA copy number analysis of supratentorial primitive neuroectodermal tumours indicates frequent alterations in the cadherin-catenin adhesion pathway.

机译：幕上原始神经外胚层肿瘤的高分辨率DNA拷贝数分析表明，钙粘蛋白-连环蛋白的粘附途径经常发生变化。

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Supratentorial primitive neuroectodermal tumours (sPNET) are highly malignant pediatric brain tumours, but the events contributing to sPNET pathogenesis are not well described. I have utilized high resolution DNA copy number and gene expression analysis in order to map candidate disease genes and obtain a comprehensive characterization of the molecular aberrations present in sPNET. DNA copy number analysis of the largest collection to date (n=44) confirmed that sPNET are genetically distinct from other CNS PNET such as medulloblastoma. sPNET are genetically heterogeneous, and known and novel genes with copy number aberrations were identified. Focal genomic deletions and gene expression analysis indicated frequent deregulation of intercellular adhesion in sPNET. This thesis focused on the characterization of PTPRM. Preliminary experiments demonstrated an inhibition of cell growth in one PNET cell line but not the sPNET-derived cell line after PTPRM reconstitution, suggesting that PTPRM inhibition of PNET may be cell-type specific.

机译：幕上原始神经外胚层肿瘤（sPNET）是高度恶性的小儿脑肿瘤，但促成sPNET发病机理的事件并未得到很好的描述。我已经利用高分辨率的DNA拷贝数和基因表达分析来定位候选疾病基因并获得sPNET中分子畸变的全面表征。迄今为止最大的DNA拷贝数分析（n = 44）证实sPNET在遗传上不同于其他中枢神经系统PNET，例如髓母细胞瘤。 sPNET具有遗传异质性，并鉴定了已知和新颖的具有拷贝数异常的基因。局部基因组缺失和基因表达分析表明，sPNET中细胞间粘附的频繁失调。本文着重于PTPRM的表征。初步实验表明，在PTPRM重组后，一种PNET细胞系中细胞生长受到抑制，而sPNET来源的细胞系中没有抑制，这表明PTPRM对PNET的抑制可能是细胞类型特异性的。

著录项

作者
Lee, Kyle Francis.;
展开▼
作者单位

University of Toronto (Canada).;

展开▼
授予单位 University of Toronto (Canada).;
学科 Biology Molecular.;Health Sciences Oncology.;Biology Genetics.
学位 M.Sc.
年度 2009
页码 89 p.
总页数 89
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: An international individual patient data meta-analysis [J] . VonBuerenA.O., GerssJ., HagelC., Journal of neuro-oncology. . 2012,第2期

机译：中枢原始神经外胚层肿瘤和松果体区域肿瘤中的DNA拷贝数改变：国际个人患者数据荟萃分析
2. DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: An international individual patient data meta-analysis [J] . VonBuerenA.O., GerssJ., HagelC., Journal of neuro-oncology. . 2012,第2期

机译：DNA拷贝数次数改变中央原始神经分区肿瘤和松果区域的肿瘤：国际个体患者数据META分析
3. Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood. [J] . Kraus JA, Felsberg J, Tonn JC, Neuropathology and applied neurobiology . 2002,第4期

机译：TP53，PTEN，CDKN2A，EGFR，CDK4和MDM2肿瘤相关基因在儿童幕上原始神经外胚层肿瘤和成胶质细胞瘤中的分子遗传分析。
4. A Computational Method to Predict DNA Copy Number Alterations from Gene Expression Data in Tumor Cases [C] . Huimin Geng, Wing C. Chan, Hesham H. Ali Hawaii International Conference on System Sciences . 2009

机译：预测肿瘤病例中基因表达数据的DNA拷贝数改变的计算方法
5. Molecular analysis of candidate tumor suppressor genes in medulloblastoma and supratentorial primitive neuroectodermal tumor [D] . Chang, Qing 2005

机译：髓母细胞瘤和幕上原始神经外胚层肿瘤候选抑癌基因的分子分析
6. The tumour-associated carbonic anhydrases CA II CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis [O] . Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, 2010

机译：一组髓母细胞瘤和幕上原始神经外胚层肿瘤中与肿瘤相关的碳酸酐酶CA IICA IX和CA XII：CA IX与不良预后的关联
7. DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis [O] . von Bueren, André O, Gerss, Joachim, Hagel, Christian, 2012

机译：中枢原始神经外胚层肿瘤和松果体区肿瘤中的DNA拷贝数改变：国际个人患者数据荟萃分析

High resolution DNA copy number analysis of supratentorial primitive neuroectodermal tumours indicates frequent alterations in the cadherin-catenin adhesion pathway.

摘要

著录项

相似文献

相关主题

期刊订阅