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Bone marrow dosimetry via microCT imaging and stem cell spatial mapping.

机译：通过microCT成像和干细胞空间定位进行骨髓剂量测定。

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摘要

In order to make predictions of radiation dose in patients undergoing targeted radionuclide therapy of cancer, an accurate model of skeletal tissues is necessary. Concerning these tissues, the dose-limiting factor in these therapies is the toxicity of the hematopoietically active bone marrow. In addition to acute effects, one must be concerned as well with long-term stochastic effects such as radiation-induced leukemia. Particular cells of interest for both toxicity and cancer risk are the hematopoietic stem cells (HSC), found within the active marrow regions of the skeleton. At present, cellular-level dosimetry models are complex, and thus we cannot model individual stem cells in an anatomic model of the patient. As a result, one reverts to looking at larger tissue regions where these cell populations may reside.;To provide a more accurate marrow dose assessment, the skeletal dosimetry model must also be patient-specific. That is, it should be designed to match as closely as possible to the patient undergoing treatment. Absorbed dose estimates then can be tailored based on the skeletal size and trabecular microstructure of an individual for an accurate prediction of marrow toxicity. Thus, not only is it important to accurately model the target tissues of interest in a normal patient, it is important to do so for differing levels of marrow health.;A skeletal dosimetry model for the adult female was provided for better predictions of marrow toxicity in patients undergoing radionuclide therapy. This work is the first fully established gender specific model for these applications, and supersedes previous models in scalability of the skeleton and radiation transport methods. Furthermore, the applicability of using bone marrow biopsies was deemed sufficient in prediction of bone marrow health, specifically for the hematopoietic stem cell population. The location and concentration of the HSC in bone marrow was found to follow a spatial gradient from the bone trabeculae in lymphoma patients. Interestingly, chemotherapy was not found to effect the HSC population in concentration or gradient. Together, this work will provide more realistic and accurate dosimetry in internal radiation therapy of cancer patients.
机译：为了预测接受靶向放射性核素治疗的癌症患者的放射剂量，必须建立准确的骨骼组织模型。关于这些组织，这些疗法中的剂量限制因素是造血活性骨髓的毒性。除了急性影响外，还必须关注长期随机影响，例如辐射诱发的白血病。在毒性和癌症风险方面都特别感兴趣的细胞是造血干细胞（HSC），位于骨骼的活动骨髓区域内。目前，细胞水平的剂量测定模型很复杂，因此我们无法在患者的解剖模型中对单个干细胞进行建模。结果，人们转向寻找可能存在这些细胞群的较大组织区域。为了提供更准确的骨髓剂量评估，骨骼剂量模型也必须针对患者。即，其应该被设计为与正在接受治疗的患者尽可能地匹配。然后可以基于个体的骨骼大小和小梁微结构来定制吸收剂量的估计值，以准确预测骨髓毒性。因此，不仅要对正常患者的目标靶组织进行精确建模，而且对于不同水平的骨髓健康也很重要。；提供了成年女性的骨骼剂量模型，可以更好地预测骨髓毒性在接受放射性核素治疗的患者中。这项工作是针对这些应用程序的第一个完全建立的针对性别的模型，在骨骼和辐射传输方法的可伸缩性方面取代了先前的模型。此外，使用骨髓活检标本被认为足以预测骨髓健康，特别是对于造血干细胞群体。发现在淋巴瘤患者中，HSC在骨髓中的位置和浓度遵循从骨小梁起的空间梯度。有趣的是，未发现化学疗法以浓度或梯度影响HSC群体。总之，这项工作将为癌症患者的内部放射治疗提供更现实，更准确的剂量。

著录项

  • 作者

    Kielar, Kayla N.;

  • 作者单位

    University of Florida.;

  • 授予单位 University of Florida.;
  • 学科 Engineering Biomedical.;Health Sciences Oncology.;Physics Radiation.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 245 p.
  • 总页数 245
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:38:25

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