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The epidemiology of sexually transmitted infections and adverse pregnancy outcomes among pregnant STD clinic attendees.

机译:性病感染的流行病学和怀孕的性病门诊参与者中的不良妊娠结局。

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摘要

Objectives. A primary goal of STI detection and treatment is to prevent adverse pregnancy outcomes (APOs). We sought to test the association of STIs and APOs (preterm birth and low birth weight) among pregnant women who sought STD clinical services.; Methods. We conducted a case-control study of pregnant women ages 13-49 who attended STD clinics in Baltimore, MD during 1996-2002 and were tested for bacterial vaginalis (BV), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), early syphilis (ES), and Trichomonas vaginalis (TV). We linked STD clinic data with state birth records to test the association of STIs and APOs. Cases were women who delivered preterm and/or low birth weight newborns and were compared with controls using multiple logistic regression.; Results. Among 1531 pregnant women, 767 (50%) had singleton births with post-natal data available. There was a 23% prevalence of APOs (6.9% preterm birth; 4.2% low birth weight, and 11.9% preterm birth and low birth weight). 97% of pregnant women were African American (mean age = 22.3); 39% reported prior spontaneous or elective termination of pregnancy, and 60.1% of women reported at least 1 antenatal care visit in the 1st trimester of pregnancy. Prevalence of maternal infection was 54.7% (BV: 30.5%; CT: 14.0%; NG: 7.3%; TV: 14.7%; ES: 0.8%). Adjusting for age and maternal weight gain during pregnancy, CT in the 1st trimester of pregnancy was associated with term delivery of a low birth weight newborn (aOR=3.44, CI 1.09-10.82, p=0.04). NG, diagnosed any time in pregnancy, was associated with preterm delivery of a normal birth weight newborn (aOR=2.50, CI 1.03-6.06, p=0.04), adjusting for age, medical factors in pregnancy, and history of NG infection.; Conclusions. STIs and APOs were prevalent among pregnant STD clinic attendees. Prospective studies designed to further elucidate the relationship of STIs and APOs are needed. The STD clinic visit may represent a critical opportunity to target interventions that will improve perinatal outcomes. Future interventions should include: enhanced counseling messages and case management, including follow-up care, and referral to substance abuse rehabilitation and antenatal care programs.
机译:目标。 STI检测和治疗的主要目标是预防不良妊娠结局(APO)。我们试图在寻求性病临床服务的孕妇中测试性传播感染和APO(早产和低出生体重)的关联。方法。我们对1996-2002年间在马里兰州巴尔的摩市STD诊所就诊的13-49岁孕妇进行了病例对照研究,并对其进行了细菌阴道炎(BV),沙眼衣原体(CT),淋病奈瑟氏菌(NG)和早期梅毒的检测。 (ES)和阴道毛滴虫(TV)。我们将性病诊所的数据与州出生记录相关联,以测试性传播感染与APO的关联。病例为分娩早产和/或低出生体重新生儿的妇女,并使用多元逻辑回归与对照组进行比较。结果。在1531名孕妇中,有767名(50%)拥有单胎婴儿的出生后数据。 APO的患病率为23%(早产6.9%;低出生体重4.2%,早产和低出生体重11.9%)。 97%的孕妇是非裔美国人(平均年龄= 22.3); 39%的人报告称先前自然或自愿终止妊娠,而60.1%的妇女报告在妊娠的前三个月中至少进行了一次产前检查。孕妇感染率为54.7%(BV:30.5%; CT:14.0%; NG:7.3%; TV:14.7%; ES:0.8%)。调整怀孕期间的年龄和孕产妇体重增加后,妊娠第一三个月的CT与足月分娩低出生体重新生儿的出生相关(aOR = 3.44,CI 1.09-10.82,p = 0.04)。 NG,在怀孕的任何时候被诊断出,都与早产新生儿的正常出生体重有关(aOR = 2.50,CI 1.03-6.06,p = 0.04),并根据年龄,怀孕的医学因素和NG感染史进行了调整。结论。性传播感染和APOs在怀孕的性病门诊患者中普遍存在。需要进行前瞻性研究以进一步阐明性传播感染与APO的关系。性病门诊可能是一个关键机会,可以针对性地采取干预措施,以改善围产期结局。未来的干预措施应包括:加强咨询信息和案件管理,包括后续护理,并转介药物滥用康复和产前护理计划。

著录项

  • 作者

    Johnson, Hope Leanne.;

  • 作者单位

    The Johns Hopkins University.;

  • 授予单位 The Johns Hopkins University.;
  • 学科 Health Sciences Obstetrics and Gynecology.; Health Sciences Public Health.; Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 333 p.
  • 总页数 333
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇幼卫生;预防医学、卫生学;
  • 关键词

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