• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Relationship between Clostridium difficile toxin type and clinical features, severity and outcome in patients with Clostridium difficile diarrhea (CDAD).
【24h】

Relationship between Clostridium difficile toxin type and clinical features, severity and outcome in patients with Clostridium difficile diarrhea (CDAD).

机译：艰难梭菌腹泻（CDAD）患者的艰难梭菌毒素类型与临床特征，严重程度和预后之间的关系。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Clostridium difficile infection is one of the major causes of antibiotic associated diarrhea and colitis in the United States. Currently, there is a dearth of literature on the risk factors and outcomes differences between the patients with infection due to the hypervirulent strain vs. the non-hypervirulent strains. The objective of this study was to determine the relationship between C. difficile toxin type and clinical features, severity and outcome in patients with C. difficile diarrhea.;Methods. The case group included 37 patients who had infections due to hypervirulent strain (tcdC deletion) and the control group included 55 patients with other toxin types (toxin A, B, binary toxin). A univariate analysis was performed followed by a multivariable logistic regression analysis to assess the differences between cases and controls.;Results. In the multivariate analyses, we found out that being a male was a protective factor for developing the infection due to the hypervirulent strain [OR 0.33; 95% CI 0.12-0.90]. Also, the hypervirulent group has worse clinical and economic outcomes, although the differences were small and nonsignificant.;Conclusions. There may likely be no predictive risk factor for acquiring infection due to the hypervirulent strain and the acquisition may be more linked to the infection control practices of the individual hospitals or location of patients. Hence, better infection control practices may prove helpful in decreasing the overall disease burden and thus improve patient outcomes.
机译：背景。在美国，艰难梭菌感染是与抗生素相关的腹泻和结肠炎的主要原因之一。当前，关于由高毒力菌株与非高毒力菌株引起的感染患者之间的危险因素和结果差异的文献很少。这项研究的目的是确定艰难梭菌腹泻患者的艰难梭菌毒素类型与临床特征，严重程度和预后之间的关系。病例组包括37例因高毒力菌株（tcdC缺失）而感染的患者，对照组包括55例其他毒素类型（毒素A，B，二元毒素）的患者。进行单变量分析，然后进行多变量逻辑回归分析，以评估病例与对照之间的差异。在多变量分析中，我们发现由于高毒力菌株，男性是感染发展的保护因素[OR 0.33; 95％CI 0.12-0.90]。同样，尽管差异很小且无统计学意义，但高毒力组的临床和经济结局较差。由于高毒力毒株，可能没有获得感染的预测危险因素，并且获得可能与各个医院或患者所在位置的感染控制措施有更多联系。因此，更好的感染控制措施可能有助于减轻总体疾病负担，从而改善患者预后。

著录项

  • 作者

    Kachroo, Sumesh.;

  • 作者单位

    The University of Texas School of Public Health.;

  • 授予单位 The University of Texas School of Public Health.;
  • 学科 Epidemiology.;Public health.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 74 p.
  • 总页数 74
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号