Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea

Hanna Pituch; Deborah Kreft; Piotr Obuch-Woszczatyński; Dorota Wultańska; Felicja Meisel-Miko?ajczyk; Miros?aw ?uczak; Alex van Belkum

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Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea

机译：波兰完整的艰难梭菌相关性腹泻患者中艰难梭菌完整毒素A，毒素B和二元毒素基因的克隆传播

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Clinically relevant Clostridium difficile strains usually produce toxins A and B. Some C. difficile strains can produce an additional binary toxin. We report clonality among five strains carrying all toxin genes from Polish patients with C. difficile-associated diarrhea. In another strain, possible recombination between binary toxin genes is documented.

机译：临床上相关的艰难梭菌菌株通常产生毒素A和B。某些 C。艰难梭菌菌株可产生另一种二元毒素。我们报道了携带 C波兰患者的所有毒素基因的五种菌株之间的克隆性。难治性腹泻。在另一种菌株中，记录了二元毒素基因之间可能的重组。 展开▼

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《Journal of Clinical Microbiology》 |2005年第1期|共4页

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Hanna Pituch; Deborah Kreft; Piotr Obuch-Woszczatyński; Dorota Wultańska; Felicja Meisel-Miko?ajczyk; Miros?aw ?uczak; Alex van Belkum;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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专利

1. Characterization of a Toxin A-Negative, Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outbreak of Clostridium difficile-Associated Diarrhea [J] . Michelle J. Alfa, Amin Kabani, David Lyerly, Journal of Clinical Microbiology . 2000,第7期

机译：难辨梭状芽胞杆菌医院相关暴发的艰难梭菌毒素A阴性，毒素B阳性菌株的表征

2. Clonal dissemination of a toxin-A-negative/toxin-B-positive Clostridium difficile strain from patients with antibiotic-associated diarrhea in Poland. [J] . Pituch H, van den Braak N, van Leeuwen W, Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2001,第8期

机译：在波兰患有抗生素相关性腹泻的患者的A型阴性/ B型阳性艰难梭菌菌株的克隆传播。

3. Correlation of Disease Severity with Fecal Toxin Levels in Patients with Clostridium difficile-Associated Diarrhea and Distribution of PCR Ribotypes and Toxin Yields In Vitro of Corresponding Isolates [J] . Thomas ?kerlund, Bo Svenungsson, ?sa Lagergren, Journal of Clinical Microbiology . 2006,第2期

机译：艰难梭菌相关性腹泻患者疾病严重程度与粪便毒素水平的相关性以及相应分离株体外PCR核型和毒素产量的分布

4. Clostridium difficile strains of swine origin: Characterization at the genetic and toxin productionlevel [C] . V. Bigouret, P. Butty, A. Horvath, Congress ofthe International Pig Veterinary Society . 2008

机译：猪血管梭菌菌株：遗传和毒素生产的表征

5. Relationship between Clostridium difficile toxin type and clinical features, severity and outcome in patients with Clostridium difficile diarrhea (CDAD). [D] . Kachroo, Sumesh. 2008

机译：艰难梭菌腹泻（CDAD）患者的艰难梭菌毒素类型与临床特征，严重程度和预后之间的关系。

6. Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A Toxin B and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea [O] . Hanna Pituch, Deborah Kreft, Piotr Obuch-Woszczatyński, 2005

机译：波兰艰难梭菌相关性腹泻患者中艰难梭菌完整毒素A毒素B和二元毒素基因的克隆传播

7. Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea [O] . Pituch, Hanna, Kreft, Deborah, Obuch-Woszczatyński, Piotr, 2005

机译：波兰艰难梭菌相关性腹泻患者中艰难梭菌完整毒素A，毒素B和二元毒素基因的克隆传播

1. 艰难梭菌毒素A/B、BD-PCR毒素基因及GDH检测对艰难梭菌相关性腹泻的诊断价值 [J] . 邵婧 ,丁宸 ,徐萍萍 . 标记免疫分析与临床 . 2016,第009期

2. 呼和浩特地区腹泻患者艰难梭菌毒素基因多位点序列分型研究 [J] . 王艳艳 ,王俊瑞 ,郑文琪 . 检验医学 . 2021,第011期

3. 艰难梭菌毒素致病基因调控机制和抗毒素治疗 [J] . 林倩云 ,费稼希 ,陈烨 . 胃肠病学 . 2017,第001期

4. 艰难梭菌毒素A B测定在医院腹泻患者中的应用价值研究 [J] . 黎华 ,陆国标 ,王穗雯 . 中国实用医药 . 2016,第016期

5. 艰难梭菌毒素AB测定在医院腹泻患者中的应用 [J] . 李文丽 ,简子娟 ,刘文恩 . 中国感染控制杂志 . 2010,第004期

6. 抗艰难梭菌B毒素单克隆抗体的制备及特性分析 [C] . 米友军 ,苏露 ,刘海 . 第十一届中国生物毒素研究及医药应用年会 . 2013

7. 多重PCR方法检测艰难梭菌毒素A基因(tcdA)、毒素B基因(tcdB)和二元毒素基因(cdtA/cdtB) [A] . 潘少敏 . 2014

1. 一种艰难梭菌二元毒素A链的适配子 [P] . 中国专利： CN109517823B . 2021.06.25

2. 一种艰难梭菌二元毒素A链的适配子 [P] . 中国专利： CN109517823A . 2019-03-26

3. OLIGONUCLEOTIDES RELATING TO CLOSTRIDIUM DIFFICILE GENES ENCODING TOXIN B, TOXIN A, OR BINARY TOXIN [P] . 外国专利： EP2534164A4 . 2013-09-11

机译：与编码毒素B，毒素A或二元毒素的梭状芽胞杆菌困难基因有关的寡核苷酸

4. OLIGONUCLEOTIDES RELATING TO CLOSTRIDIUM DIFFICILE GENES ENCODING TOXIN B, TOXIN A, OR BINARY TOXIN [P] . 外国专利： EP2534164A1 . 2012-12-19

机译：与编码毒素B，毒素A或二元毒素的梭状芽胞杆菌困难基因有关的寡核苷酸

5. OLIGONUCLEOTIDES RELATING TO CLOSTRIDIUM DIFFICILE GENES ENCODING TOXIN B, TOXIN A, OR BINARY TOXIN [P] . 外国专利： CA2814762A1 . 2011-08-18

机译：涉及编码毒素B，毒素A或二元毒素的梭状芽胞杆菌困难基因的寡核苷酸

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Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea

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