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Strategies to 'Hydrophobize' Systemic siRNA Vectors and Selectively Inhibit mTORC2 in Breast Tumors Through RNA Interference

机译：“疏水化”系统性siRNA载体并通过RNA干扰选择性抑制乳腺癌中mTORC2的策略

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Abstract not available.

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作者
Werfel, Thomas Anthony.;
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作者单位

Vanderbilt University.;

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授予单位 Vanderbilt University.;
学科 Biomedical engineering.;Chemical engineering.;Cellular biology.
学位 Ph.D.
年度 2017
页码 253 p.
总页数 253
原文格式 PDF
正文语种 eng
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专利

1. Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma [J] . Bo Fan, Lin Kang, Liqing Chen, Theranostics . 2017,第2期

机译：系统性siRNA传递与双重pH响应和肿瘤靶向的纳米载体抑制乳腺癌原位鼠模型中的肿瘤生长和自发转移。
2. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo [J] . Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Breast Cancer Research . 2008,第1期

机译：基于矢量的siRNA抑制人乳腺癌细胞中腺嘌呤核苷酸translocase-2诱导凋亡，并在体外和体内抑制肿瘤生长
3. Inhibiting tumor growth by targeting liposomally encapsulated CDC20siRNA to tumor vasculature: Therapeutic RNA interference [J] . Poulami Majumder, Sukanya Bhunia, Jayanta Bhattacharyya, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2014,第Null期

机译：通过将脂质体包裹的CDC20siRNA靶向肿瘤血管来抑制肿瘤生长：治疗性RNA干扰
4. Development of RNAi technology to selectively inhibit mTORC2 in breast cancer [C] . Thomas Werfel, Dana Brantley-Sieders, Meredith Jackson, World biomaterials congress . 2016

机译：RNAi技术的发展，选择性抑制乳腺癌中的mTORC2
5. Tumor-selective in vivo Growth Inhibitory Activities of siRNAs Targeting Kinetochore-Associated Protein 2 [D] . 蒔田幸正 2019

机译：靶向线粒体相关蛋白2的siRNA的肿瘤选择性体内生长抑制活性。
6. Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma [O] . Bo Fan, Lin Kang, Liqing Chen, 2017

机译：系统性siRNA传递与双重pH响应和肿瘤靶向的纳米载体抑制乳腺癌原位鼠模型中的肿瘤生长和自发转移。
7. Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma [O] . Bo Fan, Lin Kang, Liqing Chen, 2017

机译：用双pH响应和肿瘤靶向纳米液体递送全身siRNA递送，用于抑制乳腺癌原位小鼠模型中的肿瘤生长和自发转移
8. Assessment of Nanobiotechnology-Targeted siRNA Designed to Inhibit NF-KappaB Classical and Alternative Signaling in Breast Tumor Macrophages. [R] . Yull, F. 2014

机译：纳米生物技术靶向siRNa的评估旨在抑制乳腺肿瘤巨噬细胞中NF-κB经典和替代信号。

Strategies to 'Hydrophobize' Systemic siRNA Vectors and Selectively Inhibit mTORC2 in Breast Tumors Through RNA Interference

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