• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Early bone healing around two different experimental implant surfaces. A histologic and histomorphometric study in rabbits.
【24h】

Early bone healing around two different experimental implant surfaces. A histologic and histomorphometric study in rabbits.

机译：在两个不同的实验植入物表面周围的早期骨愈合。兔的组织学和组织形态计量学研究。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study is to compare early bone healing around different experimental implant surfaces and to evaluate the role of calcium phosphate-coated implants surface as it relates to Bone Implant Contact.;An experimental HA grit blasted and dual acid etched surface, (BAE-1) was compared to an experimental HA grit blasted and dual acid etched surface treated with nanometer-scale crystals of HA (BAE-2). Both experimental implants surfaces were implanted onto the tibias of four New Zealand white rabbits. The animals were scarified at 1,6, 21 and 90 days after implant surgery. Histological analyses were performed at the healing responses of the BAE-1 surface as compared to the BAE-2 surface, and observed at 1, 6, 21 and 90 days. Semi-Quantitative Morphology assessments were scored for three parameters: presence and extent of blood clot, mesenchymal stem cells (MSC), and presence of necrotic bone or osteocytic in the native cortical bone. Quantitative morphology assessment provided measurements of bone-implant-contact (BIC), number of bone multicellular units, average penetration of BMUs, and maximum penetration of BMUs that were manually made using Image computer software.;Microscopic evaluation of the implants in the tibiae of white rabbits at 1, 6, 21, and 90 days showed that the BAE-2 implant seemed to promote better mesenchymal stem cell migration and attachment to the implant surface at early time points when compared to the BAE-1 implant. The presence of MSC on the BAE-2 surface was recorded only after one day of healing. Both the BAE-1 and BAE-2 implants appeared to have stable anchorage into the tibial cortex in this rabbit study. The overall BIC for the BAE-2 implant was 53.1% higher than the BIC for the BAE-1 implant at 21 days and 20% higher at 90 days of healing.;The presence of MSC on the BAE-2 surface at early time points seemed to promote a faster healing process of the new bone around the implant surface when compared to the BAE-1 surface.;Although the BAE-2 implant surface appeared to provide better bone-implant contact with healthy bone remodeling, further research need to be carried out in this field.
机译：这项研究的目的是比较不同实验植入物表面周围的早期骨愈合情况，并评估磷酸钙涂层植入物表面与骨植入物接触相关的作用。;实验HA喷砂处理和双酸蚀刻表面（BAE）将-1）与经过HA喷砂处理并经HA纳米级晶体（BAE-2）处理的双酸蚀刻表面进行了比较。将两个实验植入物表面均植入四只新西兰白兔的胫骨上。植入手术后1,6、21和90天将动物吓死。与BAE-2表面相比，对BAE-1表面的愈合反应进行组织学分析，并在1、6、21和90天观察到。对三个指标的半定量形态学评估进行评分：血块的存在和程度，间充质干细胞（MSC）以及天然皮质骨中坏死骨或骨细胞的存在。定量形态学评估提供了使用图像计算机软件手动测量的骨-植入物接触（BIC），骨多细胞单位数量，BMU的平均渗透率和BMU的最大渗透率的测量值;显微镜评估了胫骨中的植入物1、6、21和90天的白兔显示，与BAE-1植入物相比，BAE-2植入物似乎在早期的时间点促进了更好的间充质干细胞迁移和附着于植入物表面。仅在愈合一天后才记录BAE-2表面上MSC的存在。在该兔子研究中，BAE-1和BAE-2植入物似乎都对胫骨皮质具有稳定的锚固作用。 BAE-2植入物的总体BIC在愈合21天时比BAE-1植入物的BIC高53.1％，而在愈合90天时则高20％.;在早期时间点，BAE-2表面上存在MSC与BAE-1表面相比，似乎可以促进植入物表面周围新骨的更快愈合过程;;尽管BAE-2植入物表面似乎提供了更好的骨-植入物接触以及健康的骨骼重塑，但需要进一步研究在这个领域进行的。

著录项

  • 作者

    Gobbato, Luca.;

  • 作者单位

    Tufts University School of Dental Medicine.;

  • 授予单位 Tufts University School of Dental Medicine.;
  • 学科 Health Sciences Dentistry.
  • 学位 M.S.
  • 年度 2010
  • 页码 74 p.
  • 总页数 74
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号