Objective: To observe the efficacy and toxicity of combined docetaxel, 5-fluorouracil and cisplatin in treatment of patients with advanced gastric cancer. Methods: Thirty-three patients with advanced gastric cancer received intravenous drip of docetaxel at a dose of 75 mg/m2 on d1 , cisplatin at a dose of 20 mg/m2 from d1 to d5 , 5-fluorouracil at a dose of 500 mg/m2 by continuous 24 h ivgtt from d1 to d5 , respectively.The treatment was repeated every 3 weeks, with evaluation of the efficacy and adverse effects after two cycles. Results:Of the 33 patients, 1 totally responded to the therapy, 16 partially responded to the medication, which was effective in 51.5％ ( 17/33 ). The median time to progression was 4.5 months, and the median overall survival was 9.9 months. Leucopenia was the major side effects. Conclusion: The combined regimen of DCF is effective and can be tolerated by patients with advanced gastric cancer.%目的:观察多西他赛联合顺铂、5-氟尿嘧啶治疗进展期胃癌的近期疗效和反应.方法:回顾性分析进展期胃癌33例,多西他赛75 mg/m2,静脉滴注,d1;顺铂20 mg/m2静脉滴注,d1 ～d5;5-Fu 500 mg/m2 24 h持续泵入,d1 ～d5.21 d为一个周期,2个周期后评价疗效.结果:全组33例患者CR 1例,PR 16例,有效率(CR+PR)51.5%(17/33),中位进展时间为4.6个月,中位生存时间为8.1个月.主要不良反应为白细胞下降.结论:DCF方案治疗进展期胃癌疗效较好,且毒副反应可以耐受.
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