二维的氧化石墨烯(GO)的细胞毒性低,且有良好的生物相容性,是良好的光热与成像材料,同时还可以作为纳米载体,用来输运化疗药物、基因等.由于氧化石墨烯的片层之间有较强的范德华力,极易团聚,从而影响其在生物医学方面的进一步应用.本文通过二硬脂酰磷脂酰乙醇胺-聚乙二醇-氨基(DSPE-PEG-NH2)功能化修饰氧化石墨烯,改善了石墨烯在水相中的稳定性、低毒性及生物相容性.功能化氧化石墨烯在水相中放置两周以上仍然具有良好的分散性,且对细胞没有明显的毒副作用,有望在生物医学领域发挥巨大作用.%Two-dimensional graphene oxide ( GO) has low cytotoxicity and good biocompatibility, which can be employed as good photothermal/imaging agents as well as nanocarriers for the delivery of chemotherapeutic drugs/genes. However, there are strong Vander Waals forces among the layer of GO, which can cause deteriorating effects of the ag-glomeration of GO, and is unfavorable for biological applications. In this work, 1, 2-distearoyl-sn-glycero-3-phosphoeth-anolamine-peg-amine ( DSPE-PEG-NH2 ) was employed to decorate GO, affording hybrid GO nanoparticles, DSPE-PEG-GO. The well-dispersed DSPE-PEG-GO was kept stable in aqueous solution for even more than two weeks, and it had no obvious cytotoxicity, which is promising in biomedicine.
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