激光作用质粒DNA和小牛胸腺DNA产生损伤效应，导致DNA结构变化。利用一种改进的试样制备过程和纳米显微镜——原子力显微镜(AFM)能够获得可重现的激光作用质粒DNA和小牛胸腺DNA的AFM图象，显示它们的特殊的表面结构，讨论了激光辐照导致DNA链断裂的作用机理。%Plasmid DNA and calf-DNA are irradiate d by laser with the samestrengty and different irradiation period.The photodama ge effects of laser a ction on DNA and the action mechanism of DNA strand breaks induced by laser radi ation are reproducible AFM images of plasmid DNA and calf DNA with laser radiati on is presented.The AFM images of DNA show their special surface structure.The a ction mechanism of DNA strand breaks induced by laser radiation discussed.
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