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首页> 外文期刊>中国药理学报：英文版 >绞股蓝总皂苷对全脑缺血再灌注损伤大鼠神经元rnDNA和RNA的保护作用
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绞股蓝总皂苷对全脑缺血再灌注损伤大鼠神经元rnDNA和RNA的保护作用

机译：绞股蓝总皂苷对全脑缺血再灌注损伤大鼠神经元rnDNA和RNA的保护作用

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目的：观察绞股蓝总皂苷(GP)对全脑缺血再灌注大鼠海马、大脑皮层、纹状体及齿状回的保护作用.方法：采用4-血管阻断(4-VO)方法建立大鼠急性全脑缺血模型，用吖啶橙染色法观察不同脑区DNA和RNA含量的变化.结果：与正常对照组比较，全脑缺血再灌注大鼠各脑区DNA和RNA吖啶橙染色后的荧光强度(反映DNA和RNA含量)明显减弱；GP100 mg/kg ig给药组各脑区DNA和RNA吖啶橙染色后的荧光强度强于全脑缺血再灌注模型组，与正常对照组相似.结论：GP明显减轻缺血再灌注对大鼠海马、大脑皮层、纹状体及齿状回DNA和RNA损伤.%AIM: To observe the protective effect of gypenosides (GP) on the neurons of hippocampus, cerebral cortex, corpus striatum, and dentate gyrus in cerebral ischemiareperfusion injury of rots. METHODS: Modified 4-vessel occlusion (4-VO) method was used to establish the model of acute global ischemia. The acridine orange (AO) staining method was used to observe the DNA and RNA contents of cerebral ischemia-reperfusion injury model in the areas. RESULTS: The fluorescent intensity (reflecting DNA and RNA contents) of the DNA and RNA in the areas of cerebral ischemia-reperfusion injury was markedly abated compared with the normal control group. In the group of ig GP (100 mg/kg) it was enhanced compared with the model group and was the same as the normal control group. CONCLUSION: The injury of the DNA and RNA in the areas of ischemia-reper-fusion model was decreased by GP.
机译：目的：观察绞股蓝总皂苷(GP)对全脑缺血再灌注大鼠海马、大脑皮层、纹状体及齿状回的保护作用.方法：采用4-血管阻断(4-VO)方法建立大鼠急性全脑缺血模型，用吖啶橙染色法观察不同脑区DNA和RNA含量的变化.结果：与正常对照组比较，全脑缺血再灌注大鼠各脑区DNA和RNA吖啶橙染色后的荧光强度(反映DNA和RNA含量)明显减弱;GP100 mg/kg ig给药组各脑区DNA和RNA吖啶橙染色后的荧光强度强于全脑缺血再灌注模型组，与正常对照组相似.结论：GP明显减轻缺血再灌注对大鼠海马、大脑皮层、纹状体及齿状回DNA和RNA损伤.%AIM: To observe the protective effect of gypenosides (GP) on the neurons of hippocampus, cerebral cortex, corpus striatum, and dentate gyrus in cerebral ischemiareperfusion injury of rots. METHODS: Modified 4-vessel occlusion (4-VO) method was used to establish the model of acute global ischemia. The acridine orange (AO) staining method was used to observe the DNA and RNA contents of cerebral ischemia-reperfusion injury model in the areas. RESULTS: The fluorescent intensity (reflecting DNA and RNA contents) of the DNA and RNA in the areas of cerebral ischemia-reperfusion injury was markedly abated compared with the normal control group. In the group of ig GP (100 mg/kg) it was enhanced compared with the model group and was the same as the normal control group. CONCLUSION: The injury of the DNA and RNA in the areas of ischemia-reper-fusion model was decreased by GP.

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