目的 研究替加环素对复杂性腹腔感染(cIAI)患者免疫功能的影响.方法 24例cIAI患者给予替加环素抗感染治疗,考察替加环素给药对患者外周血单个核细胞(PB-MC)增殖水平,炎性细胞因子分泌水平及CD3、CD4和CD8的表达水平的影响.结果 替加环素治疗cIAI总有效率为 70. 8 ％,可显著下调患者PBMC增殖水平,降低PBMC上清液和血清中白细胞介素-1β(IL-1β)、IL-6和IL-8的含量水平.此外,替加环素治疗给药可以显著上调cIAI患者外周血CD3 +、CD4+百分比和CD4 + /CD8+比值,并同时降低 CD8 +百分比.结论 替加环素对cIAI患者的免疫功能具有调控作用.%Objective To study the effects of tigecycline on immune function in patients with complicated intra-abdominal infections (cIAI). Methods A total of 24 cIAI patients received treatment of tigecycline, and then the effects of tigecycline on level of peripheral blood monouclear cells (PBMC) proliferation, concentration of inflammatory cytokines, and expression of CD3, CD4 and CD8 were investigated. Results The total effective rates of tigecycline were 70. 8％. Tigecycline treatment significantly reduced proliferative level of PBMC, decreased the levels of interleukin-1β (IL-1β), IL-6 and IL-8 in supernatants of PBMC cultures as well as serum. Moreover, tigecycline therapy significantly up-regulated the percentage of CD3 + and CD4 +, increased the ratio of CD4+ / CD8 +, and down-regulated percentage of CD8 + in peripheral blood. Conclusion Tigecycline could regulate immune function in cIAI patients.
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