Objective To investigate the 9 . 4 T of DTT in the diagnosis of SD rat C6 cerebral gliomas model about the change of CST on tumor progression and pathology confirmed. Methods ①10 μl C6 cell suspension of 106 cells number were implanted into the right caudate nucleus of brain hemisphere of 20 adult male SD rat with ster-eotactic technique. ②Application of 9. 4 T of DTT and DTI, meanwhile the routine T1-weighted imaging(T1WI), T2-weighted imaging(T2WI), contrast-enhanced T1WI,FLAIR imaging and diffusion tensor of the brain were ac-quired. Anatomic relationship between cerebral glioma and surrounding white matter fiber tracts was analyzed and measured the values of FA and MD in different areas on fractional anisotropic ( FA) map, color-coded directional map, three-dimensional (3D) white matter fiber tracts map, then stained with routine HE. Results All of SD rat C6 cerebral gliomas models 3 D white matter fiber tracts map by means of FA maps of DTI were successfully comple-ted. Apparently significant differences of FA values were found in solid tumor, surrounding edema, compared with normal white matter regions ( P0.05);there were significant differences of MD values between solid tumor, surrounding edema and normal white matter region ( P0.05)，而3个部位的测量的MD值差异有统计学意义( P<0.05)， DTT显示随着时间的推移，脊髓纤维束容易受到脑肿瘤占位、浸润、瘤周水肿带等的影响，纤维束可出现破坏和移位。结论9.4 T磁共振DTT能对不同时期SD大鼠C6胶质瘤模型做出直观观察，能较好显示皮质纤维束解剖关系的改变，病理上的改变也证实影像上的分析。
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