• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《安徽医科大学学报》 >2型糖尿病患者骨钙素与胰岛素抵抗、胰岛β细胞功能的相关性研究

2型糖尿病患者骨钙素与胰岛素抵抗、胰岛β细胞功能的相关性研究

         
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

目的 分析2型糖尿病(T2DM)患者骨钙素(OC)与胰岛素抵抗、胰岛β细胞功能的相关性.方法 测定60例T2DM患者(病例组)及20例正常人(正常对照组)的空腹血糖(FBG)、餐后2 h血糖(P2hBG)、空腹胰岛素(FINS)、空腹C肽(FCP)、糖化血红蛋白(HbA1c)、OC、脂联素(APN),用稳态模式胰岛素抵抗指数(HOMA-IR)评估胰岛素抵抗,用稳态模式胰岛素分泌指数(HOMA-B)及FCP评估胰岛β细胞功能状态.根据OC水平将病例患者分为两组,比较低骨钙素(OL)组与高骨钙素(OH)组上述指标的变化.结果 病例组FINS、FCP、HOMA-B、OC、APN明显低于正常对照组,HOMA-IR、甘油三脂(TG)高于正常对照组(P<0.05).OL组FBG、HbA1c、胆固醇(TC)、TG及HOMA-IR均高于OH组,但仅FBG、HbA1c差异有统计学意义(P<0.05);FINS、FCP、OC、APN及HOMA-B低于OH组,仅FCP、OC及APN差异有统计学意义(P<0.05).相关回归分析显示,OC与FBG、HbA1c、HOMA-IR呈负相关,与FCP、FINS、APN及HOMA-B呈正相关(P<0.05).多元线性回归分析显示,OC与FCP呈独立正相关(P<0.05).结论 T2DM患者血清OC水平的变化与胰岛素抵抗指数及胰岛β细胞功能指数的变化明显相关.%Objective To explore the relationship between serum osteocalcin level, insulin resistance and pancreatic β-cell function in type 2 diabetic patients. Methods Fasting blood glucose( FBG ), past 2 hours blood glucose ( P2hBG ), fasting insulin ( FINS ), FCP, glycosylated hemoglobin( HbAlc ), osteocalcin ( OC ) and adiponectin ( APN )were measured in 60 cases of type 2 diabetic patients and 20 controls. Homeostasis model assessment for insulin resistance index ( HOMA-IR ) was used to evaluate insulin resistance, homeostasis model assessment for insulin secretion index( HOMA-B ) and FCP were used to evaluate β-cell function. All the T2DM diabetics were divided into two groups: group OL and group OH . The differences of the indexs were compared between case group ( OL ) and normal group( OH ) to reach the relativity of osteocalcin with insulin resistance and β-cell function in type 2 diabetic patients. Results FINS , FCP, HOMA-B , OC and APN were much more lower in patients compared with controls,whereas HOMA-IR and triglycercide( TG ) were higher than those of controls ( P < 0. 05 ). FBG, HbAlc, total cholesterol ( TC ), TG and HOMA-IR were all higher in OL group compared to OH group,in which only FBG and HbAlc had significantly difference( P <0. 05 ). FINS, FCP, OC, APN and HOMA-B were lower in OL group compared to OH group, only FCP, APN and OC had significantly difference( P <0. 05 ). There was significant negative correlation between OC with FBG, HbAlc and HOMA-IR, and significant positive correlation between OC with FCP, FINS, APN and HOMA-B( P <0. 05 ). The multiple regression analysis showed that there was an independent positive correlation between OC and FCP( P <0. 05 ). Conclusion There is significant correlation between OC with HOMA-IR and HOMA-B.

著录项

相似文献

  • 中文文献
  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号