Objective To explore the relationship between serum vitamin D level and the islet B cell function as well as insulin resistance in the patients with type 2 diabetes mellitus. Methods The 25-hydroxy-vitamin D3 levels were measured in fifty patients with T2DM and forty-six healthy subjects, respectively. Insulin secretion was evaluated by HOMA-IR and IAI,and insulin resistance was evaluated by FBCI and HBCI. The linear regression analyses were conducted between vitamin D level and these indexes, respectively. Results The serum vitamin D levels were lower in the patents with T2DM than those in the healthy subjects. The vitamin D level in the patents with T2DM was positively correlated with HOMA-IR,and negatively correlated with IAI. There was no association between vitamin D level and FBCI or HBCI. Conclusions The serum vitamin D insufficiency may play a role in the pathogenesis of insulin resistance. Vitamin D supplementation may be helpful in the treatment of T2DM.%目的 观察2型糖尿病患者血清25-羟维生素D3[25 (OH) D3]水平和胰岛B细胞功能及胰岛素抵抗的关系.方法 选取确诊2型糖尿病(T2DM)患者50例,非糖尿病对照组46例,用酶联免疫吸附法(ELISA)测定所有入组者血清中25 (OH) D3含量.用稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(IAI)、胰岛B细胞功能指数(HBCI)和空腹胰岛B细胞功能指数(FBCI),评估胰岛B细胞功能及胰岛素抵抗,分析T2DM患者25( OH) D3水平和上述参数之间的相关性.结果 (1)T2DM组血清25 (OH) D3水平明显低于非糖尿病对照组(P＜0.01)；(2)T2DM组患者25( OH) D3和IR均呈正相关和IAI呈负相关.25(OH)D3水平与FBCI、HBCI无关(P＞0.05).线性回归分析提示25 (OH) D3是IR和IAI的影响因素.结论 T2DM患者体内VD水平降低,可能是其胰岛素抵抗的原因之一.补充VD可能有助于糖尿病的预防和治疗.
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