Objective To study the relationship between toll like receptor 4(TLR4) 896A>G polymorphism and the risk of ulcerative colitis (UC). Methods The English and Chinese database were searched to screen the relevant literatures. RevMan 5. 2 and Stata 11. 0 software were used for the meta-analysis and sensitivity analysis,the odds ratio (OR value) and 95％ confidence interval (95％CI) were calculated. Egger′s test was used for publication bias. Results A total of 14 articles were included in the study with 2174 UC patients and 3134 controls. Meta-analysis showed that compared with allele A,the allele G increased the risks of ulcerative colitis signif-icantly[allele model G/A:OR=1. 41,95％CI(1. 21-1. 66,P<0. 0001);dominant model AG+GG/AA:OR=1. 37,95％CI(1. 16-1. 62,P=0. 0002);recessive model GG/AA+AG:OR=3. 74,95％CI(1. 78-7. 86),P=0. 0005;co-dominant model AG/AA:OR=1. 42,95％CI (1. 07-1. 87),P=0. 01;co-dominant model GG/AA:OR=3. 85,95％CI (1. 82-8. 12),P=0. 0004]. But,the results of subgroup analysis showed that the differences only existed among caucasians in allele model G/A,dominant model AG+GG/AA and co-dominant model AG/AA. Conclusions TLR4896A>G polymorphism is associated with the susceptibility of ulcerative colitis,and the allele G increases the risks of ulcerative colitis significantly in caucasians. Due to the limited quantity of the included studies about Asian and African population,further studies are needed to validate our findings.%目的 研究Toll样受体4(TLR4)896A>G位点基因多态性与溃疡性结肠炎(UC)发病风险的关系.方法 检索相关英文及中文数据库筛选文献,以OR值及95％CI为效应指标,运用RevMan 5.2和Stata 11.0进行Meta分析和敏感性分析,并采用Egger′s test评价发表偏倚.结果 研究共纳入14篇文献,包括2174例UC患者和3134例对照者.Meta分析结果表明携带等位基因G的人群较携带等位基因A的人群患UC的风险性增加,在各个基因模型下均差异有统计学意义[等位基因模型G/A:OR=1.41,95％CI(1.21～1.66),P<0.0001;显性模型AG+GG/AA:OR=1.37,95％CI(1.16～1.62),P=0.0002;隐性模型GG/AA+AG:OR=3.74,95％CI(1.78～7.86),P=0.0005;共显性模型AG/AA:OR=1.42,95％CI(1.07～1.87),P=0.01;共显性模型GG/AA:OR=3.85,95％CI(1.82～8.12),P=0.0004].亚组分析结果表明,在等位基因模型G/A、显性模型AG+GG/AA、共显性模型AG/AA下,差异仅在白种人中存在.结论 TLR4896A>G基因多态性与UC易感性相关,携带等位基因G会增加白种人患UC的发病风险.由于该研究纳入有关亚洲人群及非洲人群的文献数量较少,相关结果需要更多研究予以验证.
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