Objective To discuss the early diagnostic value of retinol binding protein and urinary albumin on kidney damage caused by neonatal asphyxia. Methods 60 patients by neonatal asphyxia in our hospital and the Fourth Peoples Hospital of Wuxi were divided into mild asphyxia group and severe asphyxia group based on their Apgar scores,while 30 normal full-term newborn babies were selected as the control group. The content difference among the 3 groups of RBP,Alb,BUN and Cr was observed and compared. Results The RBP content of severe asphyxia group was ( 420. 5 ± 101. 4 )μg · L-1 which was obviously higher than that of mild asphyxia group and the control group( P < 0. 05 ). The RBP content of mild asphyxia group was obviously higher than that of the control group( P < 0. 05 ). The Alb content of severe asphyxia group was ( 21.41 ±8.76 )mg · L-1 which was obviously higher than that of mild asphyxia group and the control group( P <0. 05 ). The Alb content of mild asphyxia group was obviously higher than that of the control group( P < 0. 05 ). The BUN and Cr content had no difference among the three groups( P >0. 05 ). Conclusion The retinol binding protein and urinary albumin on kidney damage caused by neonatal asphyxia has a good early diagnostic value and is worthy of promotion.%目的 探讨尿视黄醇结合蛋白和尿微量白蛋白对新生儿窒息肾损害的早期诊断价值.方法 选取2010年2月至2012年2月间于我院及无锡市第四人民医院接受诊断和治疗的新生儿窒息患者60例,根据患者的Apgar评分,分为轻度窒息组和重度窒息组,另选取同期入院的正常足月新生儿作为对照组.观察比较对照组、轻度窒息组和重度窒息组患者的尿视黄醇结合蛋白(RBP)、尿微量白蛋白(Alb)以及尿素氮(BUN)和肌酐(Cr)的含量差异.结果 重度窒息组的RBP含量为(420.5±101.4)μg·L-1,明显高于轻度窒息组的(289.2±96.8)μg·L-1和对照组的(170.4±89.3)μg·L-1(P<0.05);轻度窒息组的RBP含量明显高于对照组(P<0.05).重度窒息组的Alb含量为(21.41±8.76)mg·L-1,明显高于轻度窒息组的(13.12±4.65)mg·L-1和对照组的(8.82±3.81)mg·L-1(P<0.05);轻度窒息组的Alb含量明显高于对照组(P<0.05).重度窒息组、轻度窒息组和对照组之间BUN和Cr含量比较结果 差异无显著性(P>0.05).结论 尿视黄醇结合蛋白和尿微量白蛋白对新生儿窒息肾损害早期诊断价值较高,值得推广.
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