首页> 中文期刊>亚洲传统医药 >Study of the mechanism underlying inhibitory effect of terpenoids from Daphne plants on liver cancer cells using a network pharmacology-based approach

Study of the mechanism underlying inhibitory effect of terpenoids from Daphne plants on liver cancer cells using a network pharmacology-based approach

     

摘要

Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of years.Previous studies suggested that they exerted anti-tumor activities and reported a number of compounds with anti-tumor activities,isolated from the genus Daphne.However,the targets of these compounds have not been determined yet.In this study,network pharmacology was used to analyze 128 terpenoid compounds from the genus Daphne and 49 target proteins of liver cancer.The results suggested that the target with the most number of directed edges was 5yz0.The compound which docked with 5yz0 best is AR.DT.25(acutilobin D),and the compounds with total docking score greater than 10 were almost all Daphnane diterpenoids.The network pharmacology results predicted that the 5yz0 protein was one of the potential targets of the terpenoids from the genus Daphne and then suggested several new targets and compounds for further liver cancer research.

著录项

  • 来源
    《亚洲传统医药》|2020年第5期|P.255-262|共8页
  • 作者单位

    Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

    Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

    Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

    Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

    Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    Daphne; liver cancer; terpenoids; network pharmacology;

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