A network pharmacology-based study on the effect of Periploca forrestii Schltr.on hepatocellular carcinoma

Shuang Qiu; Peng Zhao; Xiaoxiao Huang; Shaojiang Song

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A network pharmacology-based study on the effect of Periploca forrestii Schltr.on hepatocellular carcinoma

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Hepatocellular carcinoma(HCC)remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide.Numerous Chinese herbs have been used to prevent and treat HCC.Periploca forrestii Schltr.,belonging to the family of Asclepiadaceae,has been reported to have strong inhibitory efficacy against various types of cancer cells,but the mechanism is unclear.Hence,we utilized the compound-disease target network based on the network pharmacology analysis to find out the active ingredients from P.forrestii and the potential target proteins involved in hepatocellular carcinoma.The results showed that the most effective compounds in this plant might be caffeoylquinic acids and the most potential target might be GMP synthase[glutamine-hydrolyzing](PDB:2vxo).This study is of great significance to the further research of P.forrestii and provides a novel treatment strategy for HCC.

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《亚洲传统医药》 |2021年第3期|P.115-124|共10页
作者
Shuang Qiu; Peng Zhao; Xiaoxiao Huang; Shaojiang Song;
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作者单位

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning Province School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Periploca forrestii Schltr.; hepatocellular carcinoma; network pharmacology;

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A network pharmacology-based study on the effect of Periploca forrestii Schltr.on hepatocellular carcinoma

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