Objective In order to verify the biological safety and the effect of inducing osteogenesis of two different proportions of collagen based biomimetic bone materials,the model of goat skull defect was designed.Methods First,we used trephine to make circular defect in goat skull,then the bionic bones with different proportions of collagen were implanted into the defect areas.Finally,the inflammatory response and osteogenesis in the bone defect areas were observed after implantation.Results Most of the A group materials with high collagen content were mostly degraded and partly induced into bone,while the B group with low collagen content was not degraded and had no effect on bone formation.After the two groups of materials were implanted into the goats,there were no inflammatory reactions,which meant that the collagen based biomimetic bone material had good biocompatibility.Conclusions The collagen based biomimetic bone material has good biocompatibility,good biodegradability,and a certain effect on bone formation.%目的 设计山羊颅骨缺损模型以验证自主研发的两种不同配比胶原基仿生骨材料的生物安全性和诱导成骨效果.方法 首先使用环钻在山羊颅骨上制作圆形缺损区,再将胶原配比不同的仿生骨材料植入缺损区,观察材料植入后的炎症反应及缺损区域成骨情况等.结果 胶原蛋白含量高的A组材料大部分降解且部分诱导成骨,胶原蛋白含量低的B组材料基本不降解且无诱导成骨效果.两组材料植入山羊体内后,均未出现炎症反应,说明自主研发的胶原基仿生骨材料的生物相容性良好.结论 自主研发的胶原基仿生骨材料生物相容性和降解性良好,有一定的诱导成骨效果.
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