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口腔颌面外科杂志

口腔颌面外科杂志

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Journal of Oral and Maxillofacial Surgery
本刊是我国口腔颌面外科界最早的一本专业性学术期刊。主要刊登口腔颌面外科及相关学科的基础与临床研究的新成果、新技术，以及临床经验等文摘。设有专家论坛、基础研究、临床研究、临床总结、病例报道、综述、讲座等栏目。内容丰富、信息量大、读者面广，深受口腔医学院师生、口腔颌面外科和相关学科的医务人员及科技工作者的欢迎。
  • 发文量：2813
  • 被引量：11499
  • H指数：1
  • 开始收录时间：1991(1)
  • CNKI综合因子：0.271
  • 维普期刊影响因子： 0.66
  • 万方期刊影响因子：0.98
  • 创刊时间：1991
  • 国内刊号/CN：31-1671/R
    国际刊号/ISSN：1005-4979
  • 发行周期：双月刊
    邮发代号：4-532
  • 主管单位：中华人民共和国教育部
    主办单位：同济大学
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  • 邮箱：omsj399@163.com
  • 地址：上海延长中路399号
  • 邮编：200072
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口腔颌面外科杂志 >2023年第5期

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  • 摘要：目的:观察硫酸钙、β-TCP(β-磷酸三钙)及生物玻璃(倍骼生)在颌骨囊肿治疗中的疗效.方法:颌骨囊肿病例45例,行囊肿刮除术后,随机分为4组,骨腔内填充不同物质.A组:硫酸钙组;B组:β-TCP组;C组:生物玻璃(倍骼生)组;D组:空白组.术后观察患者术区肿胀程度,且1、3、6、12个月后拍摄CBCT或全景片,观察术区骨愈合情况.结果:A组患者术后1周内术区肿胀明显;A、C组患者6个月后,术区与正常骨组织无明显区别;B组患者12个月后,新骨几乎充填整个骨腔;D组新骨形成明显较A、B、C组慢.结论:在新骨形成方面,A、B、C组分别与D组相比,差异均有统计学意义;硫酸钙会引起部分患者术区肿胀反应.%Objective:To observe the different effect of medical calcium,β-tricalcium phosphate (β-TCP)and Perioglas in the treatment of odontogenic cysts cavities. Methods:Screen 45 cases of jaw cyst randomly. After cyst curettage operation, according to the different bone cavity filling materials, these cases divided into four groups, Group A: Medical calcium;Group B: Calcium phosphate; Group C: Perioglas; Group D: Blank group. Observations included the swelling degree of surgical site; Regular x-ray examination was performed at 1, 3, 6, 12 months intervals to realise the bone regeneration. Results: Group A: the swelling of surgical site was obvious after operation. Group A and group C: After 6 months of operation, there was no significant difference between the operative region and surrounding normal bone tissue. Group B:12 months later, the material was completely absorbed, and the new bone was almost filled with the whole bone cavity. Group D: The rate of the new bone formation was significantly retarded than that of A, B, and C groups. Conclusion:Comparison between group A, B, C and group D, the rate of new bone formation differed significantly. Medical calcium sulfate could cause swelling reaction in the operation area.
  • 摘要：Maxillofacial space infections are commonly seen in oral and maxillofacial surgery clinical practice. This pa-per reports a rare case of the destruction of the mandibular condyle in a patient complicated with temporal space infection, and reviews the literatures from home and abroad.%颌面部间隙感染目前仍然是口腔颌面外科的常见多发病.随着抗生素的普遍使用,口腔颌面间隙感染发病率呈上升趋势.由于颌面部特殊的解剖结构,颌面间隙感染的并发症较多且危险.预防颌面感染并发症成为治疗颌面间隙感染的治疗的关键.颌面间隙感染并发髁状突破坏在国内外鲜有报道,本文将报道1例颞下间隙感染并发髁状突破坏的病例,并对国内外文献进行回顾.
  • 摘要：目的:探讨半导体激光在种植体周围炎治疗中的作用,为临床应用提供实验依据.方法:6只实验用比格犬共植入36枚种植体,建立种植体周围炎动物模型后测量种植体周临床指标作为基线数据.然后将36枚罹患种植体周围炎的种植体随机分为3组,A组采用常规刮治,B组采用常规刮治+盐酸米诺环素软膏(派丽奥),C组为常规刮治+盐酸米诺环素软膏(派丽奥)+半导体激光照射.治疗4周后通过大体观察、临床有效率和组织学切片进行组间比较.结果:建模时3组各项检查指标差异均无统计学意义(P>0.05).治疗4周后C组的临床有效率最高,B组次之,A组最低(91.67%>75.00%>41.67%),其中C组PLI和SBI指标均优于B组[(0.25±0.45)vs(0.67±0.49),(0.33±0.49)vs(0.75±0.45),P<0.05].组织学观察发现C组种植体颈部新生骨组织较多,垂直向骨缺损最小.结论:半导体激光在种植体周围炎治疗中可有效减少牙龈出血和病原菌量并能促进新骨形成,可作为种植体周围炎治疗的辅助手段.%Objective: To explore the treatment effect of semiconductor laser on peri-implantitis treatment, and provide guidance for clinical application. Methods: 6 beagle dogs installed with 36 immediate implants were used to establish the peri-implantitis animal model. Clinical data related to the implantation were measured as baseline data. According to the treatment procedures, 36 implants suffering from peri-implantitis were randomly divided into 3 groups, Group A was treat-ed by conventional curettage. Group B was treated by conventional curettage + sulcus Periocline injection. Group C was treated by conventional curettage + sulcus Periocline injection + semiconductor laser irradiation. 4 weeks after treatment, general observation, clinical efficiency, and histological features between three groups were compared. Results: At base-line, there was no significant difference between the 3 groups (P>0.05). After treatment, significant differences manifested in the clinical efficiency (group C 91.67%>group B 75.00%>group A 41.67%). Plaque index and gingival bleeding index in Group C were better than those in Group B (P<0.05). The histological sections showed that there were more new bone tissue in the areas near implants' neck in group C, with the least the bone defect area. Conclusion: Semiconductor laser can effectively reduce gingival bleeding and pathogenic bacteria, and can promote new bone formation in the treatment of peri-implantitis, so it can be used as an adjunctive therapy for peri-implantitis.
  • 摘要：双膦酸盐相关性颌骨坏死(bisphosphonate-related osteonecrosis of the jaw,BRONJ)近年来呈现逐渐增多的趋势,本文详细报道了种植术后发生的双磷酸盐相关性颌骨骨坏死病例的临床表现、诊断与治疗,并结合文献讨论了可能的发病机制、治疗方案及对口腔种植的影响,以提高口腔医师对这一疾病的防治意识.%Recently, an increasing number of cases of jaw necrosis associated with oral bisphosphonates has been re-ported. Herein we describe a case of BRONJ after dental implant. The definitive diagnosis was derived from the medical history, clinical features, orthopantomography/computed tomography (CT). The systemic status of the patient was relatively compromised. A review of the literature provides answers to key clinical questions for dentists in the care of patients who are receiving oral bisphosphonates.
  • 摘要：口腔头面部疾病及外伤均可导致口腔颌面部及牙齿周围骨组织缺损.组织工程骨是修复口腔颌面部骨和牙周组织缺损的重要手段,而理想的种子细胞是得到组织工程骨的必要条件.牙髓干细胞容易获取,病原携带率低,培养效率高,具有成骨分化能力,与多种生物活性材料亲和性高,是组织工程修复骨缺损的理想种子细胞.本文对牙髓干细胞在口腔颌面部及牙周组织工程骨中的应用研究进展进行综述.%Maxillofacial and periodontal bone defect can be caused by multiple diseases. Bone tissue engineering is an effective method to repair bone defects in maxillofacial and periodontal area. To achieve this, ideal seed cells are essential. Dental pulp stem cells (DPSCs) have been demonstrated to possess several appealing qualities: convenient access to the collection site, low morbidity, high efficiency during extraction and culture, osteogenic differentiation potential, and high interactivity with scaffold materials. Hence DPSCs become an ideal seed cell for tissue-engineered bone. In this review, we will look into the applications of DPSCs in maxillofacial and periodontal tissue-engineered bone.
  • 摘要：Cleft surgery requires an expert team performing ongoing treatment in order to achieve optimal outcomes. The senior author's (KES) experiences of more than 2 000 patients with cleft lip and palate treated by a surgical-orthodontic protocol were introduced. The paper here will concentrate on not only correcting the occlusion as others have described, but also on what one surgeon can do to achieve optimal aesthetic balance, harmony and beauty. The results of orthognathic surgery in respect to function, stability, cosmesis, and complications are also audited.
  • 摘要：目的：探究不同年龄段兔颞下颌关节（TMJ）关节盘、髁突和软骨下骨的生理特征的变化。方法：选取1、4、12和32周龄健康雌性新西兰大白兔各3只，取材TMJ，经脱钙处理后进行5μm 连续切片，苏木精-伊红染色。分别对关节盘大小、髁突前后径，以及关节盘所对应软骨下骨的形态结构和骨密度进行测量分析。采用SPSS19.0软件包对数据进行统计学分析。结果：关节盘大小比较，4周组明显大于1周组（P=0.039），12周组明显大于4周组（P=0.007）；髁突前后径在4周和12周组间（P=0.003）显著增加；软骨下骨的形态结构和骨密度在4~32周内（P<0.05）显著改变。结论：兔颞下颌关节关节盘和髁突在青春期前生长发育明显；髁突软骨下骨的形态结构和骨密度在4周时开始出现明显改变。虽然青少年期和成年期兔髁突大小没有统计学差异，但是两者软骨下骨的骨质密度差异明显。%Objective:To study the age-related changes of articular disc, condyle and subchondral bone in rabbit temporo-mandibular joint (TMJ). Methods:Three New Zealand rabbit in each group were obtained at the ages of 1-,4-,12-and 32-week, respectively. Animals were sacrificed and TMJ specimen was subjected to histolgical assessment to evaluate about the length of articular disc and condyle and the architecture of subchondral bone. One-way ANOVA using SPSS 19.0 soft-ware package was performed. Results:Articular disc significant elongated from 1-week to 4-week rabbits (P=0.039) and 4-week to 12-week rabbits (P=0.007). The increase of subchondral bone density (P<0.05) occurred from 1- week to 4-week and 4- week to 32- week rabbits respectively. The significant enlargement of condyle length occurred from 4- week to 12-week rabbits (P=0.003). Conclusion:The growth and development potential of the articular disc and the mandibular condyle were promintly before the adolesence. The morphology structure and bone mineral density of subchondral bone changed from 4 to 32 weeks after birth, resulting in the condyle enlargement at first and the increase of bone density after-wards. In additon, there was no significant changes in condylar cartilage between adolescence and adulthood. However, the architecture of the adulthood subchondral bone was much stronger than the adolescence condyle. These provided histologi-cal basis for adulthood mandibular condyle had a stronger adaptive capacity to alteration of pressure microenvironment in temporomandibular joint.
  • 摘要：Objective:To investigate the differences of serological profiles in primary Sjögren’s Syndrome (pSS) and eval-uate their correlation with the clinical characteristics of parotid glands. Methods: The retrospective study included 289 patients who fulfilled the diagnosis for pSS adviced by American-European Consensus Group Criteria in 2002. The patients were categorized by the clinical features of parotid glands: group1 (massive group), group 2 (infection group), group 3 (swelling group) and group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance. Results: There was differences of serological profiles in accordance with the different clinical characteristics of parotid glands of pSS patients. Serum IgG value in Group 1 was the greatest, and complement C4 was lowest in four groups. Serum IgE value in Group 2 was the greatest and ESR in Group 3 was the greatest among the four groups. Conclusion: This study demonstrates the differences of serological profile in different clinical features of parotid glands of pSS patients, which may be benefit to advance our understanding of the disease.%目的：研究不同腮腺症状的原发性舍格伦综合征（ primary Sjögren’s syndrome，pSS）患者之间的血清学特征的差异性。方法：回顾性研究289名患者，均符合原发性舍格伦综合征（2002年修订的欧美联合诊断标准）。依据患者腮腺的临床特征，将患者分为以下4组：第1组（类肿瘤组）、第2组（感染组）、第3组（肿大组）、第4组（口干组）。对比各组之间的人口统计学和血清学特征。每两组之间结果的统计学分析用t检验，F检验，卡方检验，方差分析。结果：不同的腮腺临床特征的pSS患者具有不同的血清学表型。第1组的血清免疫球蛋白IgG值是4组中最高的，而补体C4是4组中最低的。第2组的血清免疫球蛋白IgE值是4组中最高的。第3组的血沉值是4组中最高的。结论：不同腮腺临床症状的pSS患者具有不同的血清学表型。这可能有助于增进我们对该疾病的认识。
  • 摘要：Objective: To investigate the clinical value of a modified decompression drainage device in the treatment of large mandibular odontogenic cystic lesions. Methods:11 cases of large mandibular cystic lesions were retrospectively re-viewed. Among them, the mandibular keratocyst (10 cases) single capsular type ameloblastoma (1 case). The patient wore a modified form negative pressure drainage device and review once a month. Results: The device effectively maintained the negative pressure in situ in all cases. Conclusion: The modified suction cyst plug is an ideal device for decompression and suction drainage in the treatment of large mandibular odontogenic cystic lesions.%目的：探讨改良型负压引流器在大型下颌骨囊性病变开窗术后的临床应用。方法：观察11例改良型负压引流器在大型下颌骨囊性病变中的应用，其中下颌骨大型角化囊性瘤10例，下颌骨单囊型成釉细胞瘤1例。遵医嘱佩戴改良型负压引流器，1个月复诊1次。结果：所有病例中，该装置均能完全与组织边缘贴合，负压保持良好。结论：改良型负压引流器是大型下颌骨囊性病变负压引流术治疗中较理想的装置。
  • 摘要：AMD3100, trade name Plerixafor, is one of mobilization agents used for hemopoietic stem cell transplantation. Due to its specific pharmacological effects of blocking the SDF-1/CXCR4 biological axis, AMD3100 can mobilize hematopoietic stem cells (HSC), endothelial progenitor cells (EPC), and mesenchymal stem cells (MSC) from bone marrow. More and more researches trying to use AMD3100 to accelerate bone regeneration. In this review we focus on the relevant researches that applying AMD3100 to accelerate bone regeneration.%AMD3100商品名为普乐沙福，是血液干细胞移植时的干细胞动员剂之一。 AMD3100具有明确阻断SDF-1/CXCR4生物轴的药理作用，能动员骨髓中的造血干细胞(hemopoietic stem cell, HSC)、内皮祖细胞(endothelial progeni-tor cell, EPC)、间充质干细胞(mesenchymal stem cell, MSC)。根据这一特点，学者们开始尝试运用AMD3100促进骨再生。本文将对运用AMD3100促进骨再生的相关研究进行综述。
  • 摘要：《口腔颌面外科杂志》的唯一在线投稿网址为http://www.kqhmwkzz.com。本网站功能包括作者投稿与查询、专家远程审稿、编辑在线加工处理稿件及发布编辑部公告。作者在线注册后即可在线投稿。文章经初审被收稿后,作者的注册邮箱将收到收稿回执;文章经专家三审并通过后,才能正式录用待发表。作者可以通过本在线系统查看稿件处理流程、审稿意见、文章录用公告和文章校样等。本刊从未委托任何其他网站或组织代为组稿,请广大作者切勿轻信,并认准本刊的官方网站投稿。
  • 摘要：Objective: This study was designed to examine condylar bone response to lateral functional shift of the mandible by examining the changes of type I/II/III collagen. Methods: Male Sprague-Dawley rats aged 4 weeks (n=40) were randomly divided into 2 groups (n=20 in each group). Rats in experiment group wore intraoral positioners, which could shift the mandibular postural position asymmetrically, whereas for the control rats no appliances were fitted. The rats were sacrificed at 1 and 4 weeks respectively. The condylar histomorphology was analyzed by hematoxylin eosin staining and safranin O staining. Picric acid-sirius red staining and immuohistochemical method were used to determine the relative content and local changes of type I/II/III collagen and then for hemi-quantitative imaging analyses. Results: Hematoxylin eosin staining and safranin O staining showed that in the experimental group, total condylar cartilage thickness on the re-gions of the contralateral side significantly increased after 1 week of functional deviation, while the total cartilage thickness on three investigated regions had no significant difference at 4 weeks. However, total condylar cartilage thickness on the three regions of the ipsilateral side had significantly decreased at 4 weeks. Results of Picric acid-sirius red staining and immuohistochemical method indicated that positive findings for type I collagen were observed from fibrous layer to chon-drocyte layer, and type II collagen were mainly observed in chondrocyte layer and hypertrophic layer. As compared with the control group, the expression of type I and type II collagen in the central region of the contralateral condyle increased significantly on 1 week and 4 weeks, while that in the lateral region of the ipsilateral condyle continued to decrease on 1 week and 4 weeks. Positive findings for type III collagen were observed from fibrous layer to chondrocyte layer, no signifi-cant differences were identified between the experimental and control groups. Conclusion: It is suggested that each side of the condylar cartilage was altered differently by functional lateral deviation of the mandible, and type I and type II collagen appeared to involve in intracartilaginous ossification during the cartilage growth and remodeling process.%目的：观察下颌骨功能性偏斜对发育期大鼠髁突软骨内I型、II型以及III型胶原纤维分布及表达的影响。方法：取4周龄雄性SD大鼠40只，随机分为实验组（20只）和正常对照组（20只）。实验组佩戴自制的上切牙金属牙套引导下颌骨功能性右偏，对照组不佩戴任何装置，分别于实验1周、4周取得标本。 HE染色及番红-O染色观察髁突软骨组织形态，苦味酸-天狼猩红偏振光染色以及免疫组化染色分别观察髁突软骨内I型、II型、III型胶原纤维含量以及分布表达情况，并进行相关半定量图像分析。结果：HE以及番红-O染色显示，实验1周后实验组牵张侧较正常组髁突软骨厚度显著增加，到4周后两组差异不显著；而实验组受压侧髁突软骨厚度4周后显著下降。天狼猩红染色及免疫组化染色结果显示，I型胶原主要表达在增殖层至成骨细胞层，II型胶原主要表达在软骨细胞层和肥大层。与正常组相比，1周及4周时实验组牵张侧软骨中区I型及II型胶原表达增强；受压侧软骨后区I型及II型胶原表达均显著减少。III型胶原主要表达在软骨纤维层至软骨细胞层，两组间无显著表达差异。结论：下颌骨功能性偏斜导致两侧髁突软骨发生了差异性生长改建，I型及II型胶原参与了改建中软骨内骨化过程。
  • 摘要：目的：探讨快速原型制作纳米-羟基磷灰石/聚己内酯（nano-HA/PCL）根形三维支架的细胞生物相容性，为进一步体内实验提供研究基础。方法：通过CT 扫描获得犬头颅骨影像信息，以CAD 软件实现犬下颌牙根形态的三维重建影像，应用快速原型（RP）技术制作nano-HA/PCL根形支架，经犬骨髓基质细胞接种后体外复合培养，检测支架材料的细胞相容性。结果：通过CT影像和快速原型技术，可实现解剖根形态结构nano-HA/PCL三维仿真支架。细胞支架复合培养后，扫描电镜显示细胞生长附着于支架表面；细胞与支架复合后增殖情况良好；7 d和14 d碱性磷酸酶活性高于对照组。结论：体外复合培养结果表明，RP技术制备的nano-HA/PCL支架和骨髓基质细胞生物相容性较好，可进一步应用于牙槽骨缺损骨组织工程修复动物实验。%Objective:To fabricate nano-hydroxyapatite/Poly-ε-caprolactone(nano-HA/PCL) scaffold with three-dimensional simulation of the root shape by using a rapid prototyping (RP) process. To evaluate biocompatibility of the scaffold used for bone tissue engineering. Methods: Parietal bone image information of canine was obtained by CT scan, three-dimensional reconstruction images were performed by CAD, roots shape nano-HA/PCL scaffolds was obtained by RP technology. Canine 3rd passage bone marrow stromal cells (BMSCs) were seeded in nano-HA/PCL scaffolds and grown in osteogenic medium. Cells were harvested after 1, 3, and 7 days. BMSCs proliferation and ALP activity were measured. Results: Scanning electron micrographs showed the BMSCs adhered to the inner surface of the scaffolds. Cell proliferation steadily increased with time, and alkaline phosphatase activity in the scaffolds at 7- day and 14- day were enhanced. Conclusion: The os-teogenic potential of BMSCs seeded at the rapid prototyped nano-HA/PCL scaffolds demonstrate a good biocompatibility, and may be effective for animal experiment in alveolar bone repair in the near future.
  • 摘要：《口腔颌面外科杂志》在各位编委的长期关心与支持下,在稿件质量、出版质量上都取得了长足的进步。现根据2014年＂总审稿篇数（5篇以上）、平均审稿天数（2周以内）、审稿质量、出席定稿会情况（3次以上）＂等综合评选,获评＂《口腔颌面外科杂志》2014年度优秀审稿专家＂的名单如下（姓氏笔画顺序）：王佐林、邓春富、卢利、孙瑶、李涛、吕春堂、张瑛、张斌、何家才、邹德荣、谷志远、周诺、姜晓钟、顾晓明、黄欣、黄洪章、常晓峰、廖建兴、翦新春。
  • 摘要：目的：探讨“基于案例”教学法（CBL）在口腔种植学教学中的应用效果及体会。方法：遴选临床真实病例资料，设计并编写CBL教学案例，通过课前导入、课中讨论、教师评价总结等课堂形式，激发学生学习的主动性，培养其独立分析、思考及解决问题的能力，帮助学生达到对理论知识的深刻理解和融会贯通。结果：超过90%的学生认为CBL教学模式能够调动学生的学习积极性，锻炼逻辑思维，提高综合运用能力。结论：高质量的教学案例是获得理想教学效果的重要保证，如何更好地运用该教学模式，仍需进行深入探讨。%Objective:To investigate the effects and practical experiences of Case-Based learning (CBL) in dental implan-tology education. Methods:The CBL cases were organized and designed before class by reference to the clinical cases. In order to make students deeply understand the lecture content, the diverse forms of teaching, such as group discussion, analysis and summary from teacher were used to stimulate the students' initiative of study and to foster their abilities of analyzing and solving problems. Results: Over 90% students thought that their study potential and logical thinking were developed. Conclusion:High quality of teaching cases is an important guarantee for ideal teaching effects of CBL. How to use this new teaching pattern better needs to be further explored.
  • 摘要：目的：研究唑来膦酸对大鼠颌骨来源的间充质干细胞增殖、成骨分化及成骨因子RANKL/OPG mRNA表达的影响。方法：体外培养新生SD大鼠颌骨来源的间充质干细胞，观察不同浓度（0、0.5、1.0、2.0、4.0、8.0μg/mL）唑来膦酸对细胞增殖的影响。观察较高浓度唑来膦酸对细胞碱性磷酸酶活性、矿化结节形成以及成骨因子 RANKL/OPG mRNA表达的影响。结果：唑来膦酸≥1.0μg/mL能明显抑制细胞增殖，低浓度（0.5μg/mL）则不影响细胞增殖，高浓度唑来膦酸（2.0μg/mL）可抑制碱性磷酸酶活性、矿化结节的形成。高浓度唑来膦酸（2.0μg/mL）能使颌骨间充质干细胞RANKL mRNA表达减少， OPG mRNA表达增加，且明显下调成骨因子RANKL/OPG比率。结论：唑来膦酸在高浓度时明显抑制颌骨来源间充质干细胞的增殖和分化，并通过调节其表面RANKL/OPG mRNA表达，抑制破骨细胞的功能，骨生成与骨吸收同时减少，骨改建过程受抑制。%Objective: To investigate the effect of zoledronic acid on the proliferation, osteogenic differentiation and the osteogenic factors RANKL/OPG mRNA expression of mandible mesenchymal stem cells(MSCs) in rats. Methods:The mes-enchymal stem cells isolated from the mandible of SD rats, were cultured with different concentrations of zoledronic acid ranging from 0~8μg/mL. At 3 days after zoledronic acid intervention, CKK-8 assay was used to measure the absorbance to detect the effect of zoledronic acid on the proliferation of mandible mesenchymal stem cells. Cell alkaline phosphatase ac-tivity, mineralized nodules formation, RANKL/OPG expression of MSCs in rats to zoledronic acid were analyzed. Results:Zoledronic acid at the concentration of ≥1.0 μg/mL could inhibit the proliferation of MSCs,but it had no effect at the concentration of 0.5 μg/mL. Zoledronic acid at the concentration of 2.0μg/mL could inhibit alkaline phosphatase activity, mineralized nodules formation of MMSCs. Zoledronic acid at the concentration of 2.0 μg/mL could down-regulate RANKL mRNA expression, but up-regulate OPG mRNA expression and down-regulate RANKL/OPG ratio. Conclusion: Zoledronic acid at high concentration can inhibit the proliferation and differentiation of MSCs. Whereas, it can inhibit the function of osteoclasts in bone remodeling by regulating the expression of MSCs cell-surface RANKL and OPG mRNA.
  • 摘要：目的：比较磨牙区即刻种植和延迟种植两种方式种植义齿的成功率。方法：198例磨牙区行种植修复的病例中，在控制适应证和患者同意的情况下，即刻种植共植入种植体67枚，延迟种植共植入种植体131枚。种植术后随访2年，观察种植体的稳定性，对两种不同种植方式的种植体的成功率进行比较。结果：67枚行即刻种植的种植体中，有4枚出现松动，成功率为94.0%；131枚行延迟种植的种植体中，有6枚出现松动，成功率为95.4%。两组种植方式成功率的比较，差异无统计学意义(P>0.05)。结论：在严格控制适应证的情况下，即刻种植也可获得较高成功率。%Objective: To evaluate the success rate between immediate and late implant placement methods in molar area implant. Methods: Under strickly indication control, molar area implant prosthesis was proceeded in 198 patients with permission. Immediate implant placement was applied in 67 patients and late implant placement was applied in 131 pa-tients. Patients were followed up for 2 years after implant installation. The implant success rate and stability between the two groups was compared. Results: Gomphiasis was arised in 4 patients who were received immediate implant placement. The success rate was 94.0%. The same situation was found in 6 patients received late implant placement. The success rate was 95.4%. No significant difference was found between these two methods (P>0.05). Conclusion: Immediate implant placement could obtain high success rate in strickly indication control patients.
  • 摘要：Objective:To evaluate the value and effects of ultrasonic scalpel in the parotid gland surgery. Methods:From June 2012 to June 2014, 36 patients were treated with superficial or total parotidectomy. Surgery indications and postoperative complications were analyzed, including the operation length, intraoperative bleeding volume, postoperative draining volume, the incidence of facial nerve injury and salivary fistulas. Results: Scalpel has the advantages of rapid cutting, hemostasis and less thermal damage. These meet the purpose of shortening the operation length, reducing bleeding and postoperative complications. Conclusion:Ultracision-harmonic scapel achieved good results in the parotid gland tumor surgery.%目的：探讨超声刀在腮腺肿瘤手术中的临床应用及效果评价。方法：对2012-06—2014-06在东南大学附属马鞍山市人民医院口腔科应用超声刀行腮腺肿瘤手术的36例病人进行回顾性分析。分析各项手术指标（手术时间、术中出血量、术后引流量）及术后并发症发生率（面神经损伤发生率、涎瘘发生率）。结果：手术时间、术中出血量、术后引流量较少，暂时性面神经损伤症状发生率、涎瘘发生率均较低。结论：超声刀以其快速切割、止血、热损伤小的优点，达到缩短手术时间、减少出血及渗出、降低术后并发症发生的目的，在腮腺肿瘤手术中取得良好的临床应用效果。
  • 摘要：中华口腔医学会口腔病理学专业委员会2015年学术年会暨口腔黏膜病临床病理和口腔病理技术研讨会定于2015年5月8日至10日在湖南省长沙市举行。本次会议由中华口腔医学会口腔病理学专委会主办,中南大学湘雅口腔医学院承办。现诚邀全国口腔病理界专家同仁积极投稿。
  • 摘要：《口腔颌面外科杂志》编辑部现已启用＂远程稿件处理系统＂,网址：http：//www.kqhmwkzz.com,欢迎广大作者在线投稿。另外,本编辑部对每篇来稿都结合数据库进行相似度检测,对相似度较高,可疑学术不端的稿件予以退稿处理。为确保稿件质量和杂志编辑工作的规范化,请作者在撰稿及投稿前仔细阅读本刊投稿须知,并严格执行。
  • 摘要：《口腔颌面外科杂志》是我国口腔颌面外科领域最早的一本专业性学术期刊。由中华人民共和国教育部主管,同济大学主办。期刊标准连续出版物号为CN 31-1671/R,ISSN 1005-4979。本刊坚持理论与实践相结合,设有专家论坛、基础研究、临床研究、口腔种植学研究、临床总结、综述、病例报告等栏目。除专家论坛以约稿为主外,其余栏目均欢迎自由来稿。并新增＂口腔医学教育＂栏目,刊登我国口腔医学教育的改革及成果,欢迎从事口腔医学教育的老师投稿。
  • 摘要：目的：研究下颌第三磨牙萌出状态与第二磨牙远中邻面龋坏的相关性。方法：临床收集因下颌第三磨牙不适而就诊的患者204例，运用锥形束CT分析下颌第二磨牙远中邻面龋坏与第三磨牙阻生类型(高位、中位、低位)、阻生角度以及两磨牙的釉牙骨质界距离（cementoenamel junction, CEJ）等因素是否存在相关性。结果：在下颌第三磨牙存在的情况下，第二磨牙远中邻面龋坏发生率高达78.4%；性别差异无统计学意义（P=0.165）；高位、中位和低位阻生的龋坏发生率差异无统计学意义（P=0.646）；而当第三磨近中阻生角度为40~80°时，第二磨牙远中邻面最易发生龋坏，与其他阻生角度组的差异有统计学意义（P<0.001）；当第二磨牙与第三磨CEJ距离在6~9 mm时，第二磨牙远中邻面龋坏高于其他组，差异有统计学意义（P<0.001）。结论：下颌第三磨牙近中阻生角度、第三磨牙与第二磨牙的CEJ距离与第二磨牙远中邻面龋坏的发生密切相关。当第三磨近中阻生角度在40~80°间，且两磨牙间的CEJ距离在6~9 mm时，第二磨牙远中邻面更容易发生龋坏，此类阻生齿建议尽早拔除。%Objective: To analyze the correlation between the eruption status of the mandibular third molar and the distal caries in the mandibular second molar. Methods: 204 patients who had eruption problems with their third molars were involved in this study. CBCT images were used to analyze the distal caries in the mandibular second molar, location of the third molars (Pell and Gregory classification), the impacted angulation of the third molar, and the distance of the cement-enamel junction (CEJ) between the second molar and third molar. Results: The prevalence of distal caries in the mandibular second molar was 78.4% when the third molar existed, and there was no difference between male and female patients (P=0.165). No significant difference was demonstrated among the Pell and Gregory classification groups ( P=0.646). The distal caries in the mandibular second molar were most prevalent where the impacted third molar situated at a mesial angle of 40~80° (P<0.001). When the distance of the CEJ between the second molar and third molar was 6~9 mm, the distal caries in the mandibular second molar was apt to occur (P<0.001). Conclusion:The distal caries in the mandibular second molar was closely related to the impacted angulation (40~80°), and the distance of the CEJ between the second molar and the third molar (6~9 mm), which kind of impacted third molar should be extracted as early as possible.
  • 摘要：目的：了解目前青少年颌骨囊性病变的构成现状,为临床诊疗提供帮助。方法：回顾性分析2003-01—2013-12间，于我科住院治疗的362例青少年颌骨囊性病变的临床资料，对其分类、性别、年龄、发病部位、治疗方法进行分析。结果：362例中成釉细胞瘤109例，牙源性角化囊性瘤107例，含牙囊肿48例，根尖囊肿24例，其他74例。平均年龄14.93岁，男女比例1.63∶1。下颌骨受累226例，上颌骨受累140例，26例患者上下颌骨同时受累，22例患者影像资料缺失，左右颌骨发病率基本相同，颌骨任一部位均可发生囊性病变，但下颌磨牙及下颌升支区为最易受累部位。结论：青少年颌骨囊性病变好发于下颌骨，男性发病率较女性高，其治疗及预后与成年人有差异，临床诊治中应注意其相应变化。%Objective: To investigate the current status of jaw cystic lesions in the adolescent patients. Methods: Retro-spective analysis of 362 cases of adolescents jaw cystic lesions treated in our department from January 2003 to Decem-ber 2013. Clinical data included cyst classification, gender, patients' age, location of the cyst, and therapeutic measures. Results: In the 362 cases, ameloblastoma 109 cases, odontogenic keratocysts 107 cases, dentigerous cysts 48 cases, radicular cysts 24 cases, and 74 other jaw cysts. Age of patients ranged from 10 to 19 years old, with a mean of 14.93 years. The distribution between males and females were about 62.15%(225/362) males to 37.85%(137/362) females (1.64∶1). 226 cases (62.43%) located in the mandible, 140 cases(38.67%) located in the maxilla. In 26 cases whose cysts located in both mandible and maxilla. In 22 cases, whose X-ray radiographs were lost. The morbidity of jaw cystic lesions is the same in both side of the jaw. The most prevalent locations of adolescent jaw cysts were the mandibular molar area and ra-mus. Conclusion: Jaw cystic lesions in adolescent patients mainly occur in the mandible. Men are more vulnerable than women. In addition, therapy and prognosis of jaw cystic lesion differs between adolescents and adults. The differences should be taken into account in daily clinical works.
  • 摘要：Objective: To review the clinical effects of a modified posterior mandibular incision approach in the reduction of condylar fractures. Methods: 18 cases were retrospectively reviewed. The occlusal, relationship, degree of mouth open-ing, facial muscle function, salivary fistula and other clinical indicators were evaluated. Results: All the patients restored to normal occlusion and normal degree of mouth opening. No facial paralysis or salivary fistulas was revealed. Three months postoperative CT images showed all patients achieved anatomical repositioning of fractured condyle. Conclusion:Modified posterior mandible incision approach demonstrates benefits in the treatment of condylar fractures.%目的：探讨经颌后切口入路治疗髁突中低位骨折的临床效果。方法：对18例经颌后入路行髁突中低位骨折切开复位内固定术进行回顾分析，评价患者张口度、开口型、咬合关系、面部表情肌功能、涎瘘等临床指标。结果：18例患者术后咬合关系、张口度、开口型均可恢复正常，无面瘫、涎瘘病例出现。术后3个月复查CT片显示髁突解剖复位，骨折断端无成角或裂开。结论：经颌后切口入路治疗髁突中低位骨折，能充分保护面神经分支，最大程度减轻对腮腺腺体创伤，且能达到髁突解剖复位和坚固内固定的治疗效果。
  • 摘要：本书从生物学基础和癌症的流行病调查开始,详细论述了癌瘤的发生、癌细胞的实验室培养技术、癌细胞的增殖与诱导分化、癌细胞的信号转导与迁移、癌基因、抑癌基因、肿瘤免疫、肿瘤病理、癌的蛋白组学及基因组学。还有癌的放射线治疗、化疗及基因靶向治疗等。全书分3编,共29章,约107万字。从全身医学到口腔癌瘤,从生物学基础理论到实验室研究,从正常组织的癌变到癌的生物学治疗,涉及面广,内容翔实。
  • 摘要：目的：通过观察整合素连接激酶（Integrin-linked kinase, ILK）与一氧化氮合酶（nitric oxide synthase，NOS）在涎腺腺样囊性癌（salivary adenoid cystic carcinoma, SACC）中的定位及表达，探讨ILK与NOS在SACC中的作用。方法：对2006-2012年吉林医药学院附属医院病理科30例SACC存档蜡块，和25例非肿瘤疾病的正常涎腺组织（对照组）行免疫组化分析，观察ILK与NOS在SACC中的表达分布情况。利用SPSS13.0统计软件分析ILK与NOS的差异性及相关性。结果：在SACC中，ILK阳性率为76.67%，eNOS阳性率为63.33%，iNOS阳性率为80%。ILK实验组与对照组比较，P<0.05；eNOS实验组与对照组比较，P>0.05；iNOS实验组与对照组比较，P<0.05。 ILK与eNOS在SACC中的表达不存在相关性；ILK与iNOS在SACC中的表达存在正相关，r=0.512。结论：ILK与iNOS在SACC中的表达存在正性相关，可能通过iNOS信号转导途径启动VEGF的表达，促进肿瘤早期的血管发生和形成。%Purpose: To examine the expressions of integrin-linked kinase (ILK) and nitric oxide synthase (NOS) and its significance in SACC. Methods:30 cases of SACC from 2006 to 2012 were used to determine the expression of ILK and NOS by immunohistochemistry examination. The correlation of ILK and NOS were statistically analyzed by SPSS software. Results: The positive rate of ILK expression was 76.67%; The positive rate of eNOS expression was 63.33%; The positive rate of iNOS expression was 80%. ILK and iNOS expression manifested significant differences between experiment and control groups;but expression of eNOS did not show statistical difference. No positive correlation of expression of ILK and eNOS in SACC was confirmed. Expression of ILK were negatively correlated with iNOS expression in SACC, r=0.512. Conclusion: The iNOS plays a role that promoting the growth of SACC and tumor angiogenesis, and eNOS effects are not obvious. ILK and iNOS positive correlation may start signal transduction pathways and motivate VEGF expression, thus promote early tumor angiogenesis and formation.
  • 摘要：Objective: To investigate the distribution of pathogenic bacteria and analyze the related influencing factors of postoperative infections in oral and maxillofacial surgery (OMFS). Methods:2012-01—2013-12, 1 652 patients underwent operation in OMFS. Postoperative infections occurred in 113 patients (6.8%). The general condition of the patient, accom-panied diseases, operation length, preoperative and postoperative medications, and cultivation of microorganisms from in-fection smear or exudates were recorded and retrospectively reviewed. Statistic analysis were tested with SPSS 17.0 pack-age software. Results: 116 strains of pathogenic bacteria were detected, Staphylococcus aureus (34 strains) and Pseu-domonas aeruginosa (27 strains) were the most popular pathogens. Postoperative infection in OMFS was also closely related to patient’s accompanied chronic diseases, perioperation medication, type of anesthesia, patient ’s age, operation length, and postoperative medications. Conclusion: Further effective prevention and control measures should be applied, to re-duce the incidence of infection after operation of oral and maxillofacial surgery.%目的：探讨口腔颌面外科手术后感染的病原菌分布特点及感染的相关影响因素，为临床防治提供依据。方法：对口腔颌面外科手术后发生感染的113例病历进行回顾性调查，分别从细菌培养、患者一般情况、基础疾病、手术时间、用药情况用等方面进行统计，应用SPSS 17.0软件对数据进行分析。结果：共分离出116株病原菌，金黄色葡萄球菌和铜绿假单胞菌检出率较高，分别占29.3%（34株）、23.3%（27株）。34株金黄色葡萄球菌中检出耐甲氧西林金黄色葡萄球菌（MRSA）15株，检出率为44.1%。术后感染与患者的基础疾病、围手术期用药、麻醉方式、患者年龄、手术时间、术后用药时间等因素密切相关。结论：必须进一步采取有效的防治措施，减少口腔颌面外科手术后感染的发生。
  • 摘要：本文简述了长链非编码RNA（lncRNA）的概念及其功能，以及目前的研究现状，介绍了当前研究较为透彻的几个lncRNA的功能以及其在肿瘤组织中的表达情况，如H19、MALAT1、MEG3、HOTAIR等。着重分析了在头颈部肿瘤研究领域，lncRNA目前的研究进展，提出lncRNA与肿瘤的发生发展关系密切，存在着广阔的研究空间。%[Absrtact] This paper briefly describes the concept and functions of lncRNA and the current situation of research, intro-duces several functions of lncRNA thoroughly researched at present and their expression in tumor tissues, such as H19, MALAT1, MEG3, HOTAIR, etc. This paper also mainly analyzes the current research progress of lncRNA in the field of head and neck tumors, and proposes that lncRNA is closely related to the occurrence and development of tumors and im-plies a broad research space.
  • 摘要：Objective:The aim of this study is to analysis the clinical significance of chronic sublinguitis. Methods:Com-bining the representative case of chronic sublinguitis, more literature review was engaged to analyze the characteristics and the best treatment method of this disease. Results: Chronic sublinguitis is low morbidity, and its clinical significances are too similar with other sublingual gland diseases to be misdiagnosed. The key points of different diagnosis between chronic infection of sublingual and other diseases (tumors of sublingual, diseases of submandibular gland, etc.), were analyzed in the article. Conclusion:A correct diagnosis and treatment is very important to chronic infection of sublingual gland.%目的：对慢性舌下腺炎进行临床分析，为临床诊治工作提供指导。方法：报道所治疗的慢性舌下腺炎1例，并结合检索复习国内外相关文献，分析慢性舌下腺炎的相关特点及临床鉴别诊断要点。结果：慢性舌下腺炎属于相对少见的涎腺疾病，其临床特点与舌下腺其他疾病均有不同程度的相似处，容易误诊，而治疗方案却又大相径庭。本文结合文献分析了该病症与舌下腺肿瘤、口底鳞癌、腺样囊性癌、黏液表皮样癌、颌下腺疾病的鉴别诊断要点。结论：临床中需要提高对慢性舌下腺炎的认识，在临床中采用合适的辅助诊断办法，制定治疗方案。

    口腔颌面外科杂志的期刊信息

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