以纳米TiO2为催化剂，靛红酸酐、2-甲酰基苯甲酸、不同芳香肼或酰肼类化合物为原料，在乙醇/水溶液为溶剂的条件下一锅法合成，高产率得到6个喹唑啉酮并酞嗪酮类化合物及10个3-酰胺基取代的异吲哚酮并喹唑啉酮类化合物。该方法简洁高效，反应条件温和，为喹唑啉酮并杂环类化合物的合成提供了一条新途径。%An efficient and simple one-pot method was developed for the synthesis of two kinds of N-fused quinazolinone derivatives using nano TiO2 particles as catalyst from isatoic anhydride, 2-carboxy benzalde-hyde, hydrazides or aromatic hydrazines. Six quinazolino[2,1-b]phthalazin-8-ones and ten 3-acylamino isoin-dolo[2,1-a]quinazolines were obtained in excellent yields, and the reaction refluxed in aqueous ethanol were environmentally friendly. Attractive features of this methodology were its versatility, mild condition and high efficiency in creating two different structures in a single operation.
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