By using 3-(1-cyanoethyl)benzoic acid methyl ester as starting material,ketoprofen was obtained by methylated with dim-ethyl sulfate,and thionyl chloride to prepare acyl chloride,Friedel-Crafts reaction with benzene,subsequently hydrolysis by sulfuric acid. The structure was confirmed by ESI-MS and 1H-NMR. Through experiment and factory enlargement,trial production proved that the optimum reaction conditions of methylation were sodium hydroxide concentration 50%,temperature 25±5℃,with a purity of 99. 81% and a total yield of 75. 71%. The new synthetic process had the advantages of cheap,mild reaction conditions,simple and easy to operate and suitable for the industrial production.%本论文以间氰甲基苯甲酸甲酯为原料,经硫酸二甲酯甲基化,氯化亚砜制备酰氯,与苯Friedel-Crafts酰化后硫酸水解得到酮洛芬;结构经ESI-MS,1H-NMR确证.通过实验与工厂放大试生产验证,甲基化的最佳反应条件为氢氧化钠浓度50%、温度25±5℃,总收率为75. 71%;HPLC纯度为99. 81%.该新合成方法原料廉价易购、反应条件温和、操作简单,适合工业化生产.
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