以2,4-二氟代联苯为原料,经傅-克酰基化、缩合、环化等反应步骤,合成了新型含联苯基的吡唑衍生物(4a～4k),其结构用红外光谱(IR)、高分辨质谱(HRMS-ESI)、核磁共振氢谱(1H NMR)、核磁共振碳谱(13C NMR)进行了表征.测试了目标化合物(4a～4k)对Aurora激酶A的抑制活性,初步的测试结果表明,化合物4f对Aurora激酶A有一定程度的抑制活性.%The novel pyrazol derivatives(4a～4k)with biphenyl were synthesized via F-C acylation,condensation,cyclization reac-tion starting from 2,4-difluorin-bipheny. The structure of the target compounds(4a～4k)were confirmed by IR,1H NMR,13C NMR and HRMS-ESI spectra. The inhibition activity for Aurora kinase A of the target compounds were tested,preliminary test results showed that the compound 4f had a certain degree of inhibitory activity for Aurora kinase A.
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