本文提供了一种简单方便的合成2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛(藏红花酸二醛)的方法,即通过2,7-二甲基-2,4,6-辛三烯二醛与3-(5,5-二甲基-1,3-二恶烷-2-基)丁-2-烯基膦酸二乙酯或(3-甲基-4-氧代-2-丁烯-1-基)膦酸二乙酯进行霍纳尔-沃兹沃思-埃蒙斯( HWE)反应,以四氢呋喃为溶剂,氢化钠或叔丁醇钾为碱来合成藏红花酸二醛。所得到的化合物经过红外,核磁共振氢谱,碳谱以及质谱确认。%A convenient preparation of 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptenedial( crocetin dialdehyde) had been developed by two-fold Horner-Wadsworth-Emmons(HWE)reaction of 2,7-dimethylocta-2,4,6-trienedial with diethyl 3-(5,5-dimethyl-1,3-dioxan-2-yl)but-2-enylphosphonate or diethyl 3-formylbut-2-enylphosphonate in THF with NaH or t-BuOK as a base. The obtained compounds were characterized through IR,1 H NMR,13 C NMR and HRMS.
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