Chitosan-N-polyethylenimine-methoxy poly ethylene glycol ( CS-N-PEI-mPEG ) was synthesized via Michael reaction of chitosan with polyethylenimine-methoxy polyethylene glycol ( mPEG-PEI) . The intermediates and final polymers were characterized by 1 H NMR and FT-IR spectroscopy. The copolymer might be a promising polymeric carrier combining low cytotoxicity and high gene transfection efficiency.%本文通过聚乙二醇化的聚乙烯亚胺与马来酰化的壳聚糖反应,得到了水溶性良好的聚乙二醇化聚乙烯亚胺接枝的壳聚糖(CS-N-PEI-mPEG),目标物用FT-IR,1H-NMR,UV-Vis进行了表征。实验表明,CS-N-PEI-mPEG对细胞的毒性低,而它的转染效率却较高。
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