设计了以2-(溴甲基)喹啉-3-甲酸乙酯(4)与2-氯-1-甲基-3-吲哚醛(5)为起始化合物，通过简便有效的“一锅法”反应，首次将吲哚环引入2-苯乙烯基喹啉骨架模型，从而得到一新颖结构的双杂环化合物，即( E)-2-(2-(2-氯-1-甲基-1H-3-吲哚基)乙烯基)喹啉-3-羧酸(3)，其结构通过波谱数据和元素分析得以证实。%In this investigation,the first introduction of indole nucleus into 2-styrylquinoline skeleton leading to a new prototype, namely(E)-2-(2-(2-chloro-1-methyl-1H-indol-3-yl)vinyl)quinoline-3-carboxylic acid(3)had been achieved through a simple and efficient one-pot reaction of ethyl 2-(bromomethyl)quinoline-3-carboxylate(4)with 2-chloro-1-methyl-indole-3-carbaldehyde(5). The molecular structure of the newly synthesized compound was confirmed on the basis of elemental analysis and spectral data.
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