报道了一种高效合成吡咯烷-2,3,5-三酮的新方法,即以二氯甲烷为溶剂,无任何催化剂存在下,α-胺/氨甲酰基二硫缩烯酮即可与草酰氯反应,以很高的产率生成吡咯烷-2,3,5-三酮。该方法反应条件温和,反应时间短,产率高,为吡咯烷-2,3,5-三酮的合成提供了新方法。%In this paper,we described a novel efficient method for preparation of pyrrolidine-2,3,5-triones via the reaction betweenα-acylamino ketene-(S,S)-acetals and oxalyl chloride in CH2Cl2 without any catalyst. Pyrrolidine-2,3,5-triones were synthesized in high yields. The reaction conditions were optimized,and a tentative reaction mechanism was proposed. The simple procedure,mild condition and high yield make this protocol most attractive for synthesis of pyrrolidine-2,3,5-triones.
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