The anti-cancer drug imatinib was synthesized through six main reactions such as cyclization,condensation,reduction and amidation etc. The after-treatment of N-( 2-methyl-5-nitrophenyl) -4-( pyridine-3-yl) pyrimidin-2-amine, the intermediate of imatinib , was optimized greatly. The improved after-treatment method featured with low cost, easy operation procedure and could be readily scale-up to mass production.%以3-乙酰基吡啶为起始原料,经环合、缩合、还原、酰胺化等六步反应制得抗肿瘤药物伊马替尼,并对其中间体N-(2-甲基-5-硝基苯基)-4-(3-吡啶基)嘧啶-2-胺的后处理工艺进行了优化,降低了成本和操作难度,有利于工业化.
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