An efficient one-pot method for synthesis of 4-arylmethylidene-l-(4'-carboxyphenyl)-3-methyl-pyrazol-5-one derivatives had been accomplished by the condensation of ethyl acetoacetate,p-carboxyphenylhydrazine and aromatic aldehydes. The results revealed that the high yields of products were obtained using piperidine as a catalyst (20% mmol) in ethanol solvent All products were characterized by 'H NMR,I3C NMR.IR and MS techniques.%本文报道了由乙酰乙酸乙酯、对羧基苯肼和芳香醛经三组分一锅法缩合制备4-芳亚甲基-1-(4'-羧基苯基)-3-甲基吡唑-5-酮衍生物的有效方法.实验结果表明,当以乙醇为溶剂,六氢吡啶为催化剂时,所得反应产率最高.所有产物均通过1H NMR,13C NMR,IR和MS技术进行了结构确定.
展开▼
