A facile and general synthesis of a series of new tropolone-based chalcone compounds by Claisen-Schmidt condensation reaction from 3-acetyl-5-bromotropolone and substituted benzaldehydes was described.The method using 5％ aq.KOH as catalyst and 50％ aq.methanol as solvent was attractive since it specifically generates(E)-isomers with high yields under mild reaction conditions.The structures of the title compounds were characterized by IR,1H NMR,and MS techniques.%3-乙酰基-5-溴-卓酚酮与不同取代的苯甲醛类化合物通过Claisen-Schmidt缩合反应合成一系列结构新颖的卓酚酮取代的查尔酮类衍生物.该方法使用5％ KOH溶液作为催化剂,50％甲醇水溶液作为溶剂,具有操作简便、反应条件温和、收率高等优点.所合成标题化合物的结构经IR、1H NMR、MS和元素分析得以证实.
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