A rapid, sensitive and accurate method was established based on gas chromatography/triple quadrupole mass spectrometry (GC-QqQ-MS/MS) to simultaneously determine three kinds of phthalate plasticizers [di (n-butyl) phthalate (DBP), butylbenzyl phthalate (BBP) , and di(2-ethylhexyl)phthalate (DEHP)] in cosmetics. To-be-measured cosmetics samples were extracted with methanol under sonication-assistance and separated with an HP-5MS analytical column (30 mXO. 25 mm (internal diameter) ×0. 25 μm film thickness). The QqQ mass spectrometer was operated in a multiple-reaction monitoring mode. The qualitative analysis of the samples was carried out by comparing the retention-time and ion-pair with that of standard material, and the quantitative analysis was carried out by comparing the abundance of the ion-pair with that of the standard material. Results indicate that the limits of detection for DBP, BBP, and DEHP in the tested samples are in the range of 12 - 28 ng/g; the relative standard deviation is in the range of 1. 6% - 7. 54% , and the recoveries are in the range of 86.4%- 121. 1%. The present method can be applied for the routine analysis of the three kinds of phthalate plasticizers in cosmetics.%建立了一种快速、灵敏、准确的三重串联四级杆气质联用(GC-MS/MS)法,将其用于同时检测化妆品中的三种邻苯二甲酸酯(邻苯二甲酸二丁酯、邻苯二甲酸丁基苄基酯、邻苯二甲酸二乙基己酯)增塑剂.化妆品经甲醇提取,HP-5 MS柱分离,采用GC-MS/MS的多反应监测模式,以保留时间和离子对(母离子和子离子)信息比较定性,以母离子和响应值高的子离子进行定量.结果表明,该方法的检出限为12～28 ng/g,相对标准偏差为1.6％～7.54％,目标物的加标回收率为86.4％～121.1％；该方法可用于检测日常化妆品中邻苯二甲酸酯的含量.
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