Objective To explore the plaque morphology of coronary heart disease and vascular active factor ET1, NO, CGRP correlation. Methods 60 cases of coronary atherosclerotic heart disease, according to the plaque morphology can be divided into type I 18 cases, type II group 28 cases, 14 cases of type III group, compare the three groups of vascular active factor, NO, ET1 CRRP, ET1/NO, ET1/CGRP and NO/CGRP level. Results Pathological morphology between type I and type II and type III ET1 and CGRP statistical differences (P<0.05), NO, ET1/NO, ET1/CGRP and NO/CGRP no statistical difference (P>0.05). Conclusion Vascular active factor level and coronary heart disease (CHD) plaque morphology has a certain relevance.%目的：探讨冠心病的斑块形态与血管活性因子ET1、NO、CGRP相关性。方法选取60例冠状动脉粥样硬化性心脏病患者，根据斑块形态学分为I型组18例、II型组28例、III型组14例，比较三组血管活性因子ET1、NO、CRRP、ET1/NO、ET1/CGRP、NO/CGRP水平情况。结果病理形态I型、II型和III型间ET1和CGRP差异存在统计学意义（P＜0.05），NO、ET1/NO、ET1/CGRP和NO/CGRP差异无统计学意义（P＞0.05）。结论血管活性因子水平与冠心病斑块形态具有一定的相关性。
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