ObjectiveTo study the paroxetine combined with cognitive behavior therapy for the treatment of patients with depression.Methods 60 hospitalized patients with a diagnosis of depression patients as the research object were randomly divided into observation group and control group, 30 cases in each group. Control group treated with paroxetine alone, observation group with paroxetine combined cognitive behavioral therapy, two groups of patients were given for 6 weeks course of treatment, the HAMD scale evaluation of two groups of patients before and after treatment the curative effect of 1, 2, 4, 6 weeks.ResultsNo difference between two groups of patients before treatment, 1, 2, 4, 6 weeks after treatment of HAMD scale evaluation effect was better than that of control group, with signiifcant difference (P<0.01).Conclusion Paroxetine combined cognitive-behavioral therapy for the treatment of patients with depression effect is signiifcant.%目的：研究帕罗西汀联合认知行为疗法对抑郁症患者的治疗效果。方法将诊断为抑郁症的住院患者60例作为研究对象，随机分为观察组及对照组，每组30例患者。对照组采用帕罗西汀单纯治疗，观察组采用帕罗西汀合并认知行为治疗，两组患者均给予以6周为疗程的治疗，采用HAMD量表评价两组患者治疗前及治疗后第1、2、4、6周的疗效。结果两组患者治疗前无差异，治疗后1、2、4、6周HAMD量表评价效果优于对照组，具有显著性差异（P＜0.01）。结论帕罗西汀联合认知行为疗法对抑郁症患者的治疗效果显著。
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